Gas-Phase Fragmentation of Peptides by MALDI in-Source Decay with Limited Amide Hydrogen (1H/2H) Scrambling

To achieve a fundamental understanding of the function of proteins and protein complexes at the molecular level, it is crucial to obtain a detailed knowledge about their dynamic and structural properties. The kinetics of backbone amide hydrogen exchange is intimately linked to the structural dynamic...

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Veröffentlicht in:Analytical chemistry (Washington) 2008-08, Vol.80 (16), p.6431-6435
Hauptverfasser: Bache, Nicolai, Rand, Kasper D, Roepstorff, Peter, Jørgensen, Thomas J. D
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Sprache:eng
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