Structures of the Toll-like Receptor Family and Its Ligand Complexes

Toll-like receptors (TLRs) play central roles in the innate immune response by recognizing conserved structural patterns in diverse microbial molecules. Here, we discuss ligand binding and activation mechanisms of the TLR family. Hydrophobic ligands of TLR1, TLR2, and TLR4 interact with internal pro...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2008-08, Vol.29 (2), p.182-191
Hauptverfasser:	Jin, Mi Sun, Lee, Jie-Oh
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Dimerization Hydrophobic and Hydrophilic Interactions Immune system Insects Ligands Lipopolysaccharide Receptors - immunology Lipopolysaccharide Receptors - metabolism Lipopolysaccharides - chemistry Lipopolysaccharides - immunology Lipopolysaccharides - metabolism Lymphocyte Antigen 96 - immunology Lymphocyte Antigen 96 - metabolism Lymphocyte receptors Protein Structure, Tertiary Proteins Receptors, Interleukin-1 - metabolism Signal transduction Toll-Like Receptors - chemistry Toll-Like Receptors - metabolism
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