Involvement of Ca2+ influx in the mechanism of tamoxifen-induced apoptosis in HepG2 human hepatoblastoma cells

The signaling mechanism of tamoxifen (TAM)-induced apoptosis was investigated in HepG2 human hepatoblastoma cells which do not express the estrogen receptor (ER). TAM induced cytotoxicity and DNA fragmentation, a hallmark of apoptosis, in a dose-dependent manner. TAM increased the intracellular conc...

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Veröffentlicht in:	Cancer letters 1999-12, Vol.147 (1-2), p.115-123
Hauptverfasser:	KIM, J.-A, YOUNGB SHIN KANG, JUNG, M.-W, SUN HEE LEE, YONG SOO LEE
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Calcium - metabolism Calcium Channel Blockers - pharmacology Cell Survival - drug effects Chelating Agents - pharmacology DNA Fragmentation Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Extracellular Space - metabolism Flufenamic Acid - pharmacology Fluorescent Dyes Fura-2 General aspects Hepatoblastoma - metabolism Hepatoblastoma - pathology Humans Intracellular Fluid - drug effects Intracellular Fluid - metabolism Ion Channels - drug effects Liver Neoplasms - metabolism Liver Neoplasms - pathology Manganese - pharmacokinetics Medical sciences Membrane Potentials - drug effects Pharmacology. Drug treatments Receptors, Estrogen Signal Transduction - drug effects Tamoxifen - antagonists & inhibitors Tamoxifen - pharmacology Tumor Cells, Cultured
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