Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model
Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury. Methods: Eighteen New Zealand white rabbits underwent midline laparot...
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| Veröffentlicht in: | The American journal of surgery 1999-12, Vol.178 (6), p.573-575 |
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| container_title | The American journal of surgery |
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| creator | Subramanian, Sreekumar Bowyer, Mark W Egan, J.Craig Knolmayer, Thomas J |
| description | Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury.
Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P |
| doi_str_mv | 10.1016/S0002-9610(99)00238-X |
| format | Article |
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Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05.
Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin.
Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(99)00238-X</identifier><identifier>PMID: 10670875</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Blood Urea Nitrogen ; Glycyrrhizic Acid - pharmacology ; Kidney - blood supply ; Kidney - physiopathology ; Rabbits ; Reperfusion Injury - physiopathology ; Reperfusion Injury - prevention & control ; Selectins - physiology ; Time Factors</subject><ispartof>The American journal of surgery, 1999-12, Vol.178 (6), p.573-575</ispartof><rights>1999 Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-6a9faa31f4f94230a82a828acd0992b34b695cebe78c61e7acdb5a168ee4fc093</citedby><cites>FETCH-LOGICAL-c361t-6a9faa31f4f94230a82a828acd0992b34b695cebe78c61e7acdb5a168ee4fc093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9610(99)00238-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10670875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Subramanian, Sreekumar</creatorcontrib><creatorcontrib>Bowyer, Mark W</creatorcontrib><creatorcontrib>Egan, J.Craig</creatorcontrib><creatorcontrib>Knolmayer, Thomas J</creatorcontrib><title>Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury.
Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05.
Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin.
Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model.</description><subject>Animals</subject><subject>Blood Urea Nitrogen</subject><subject>Glycyrrhizic Acid - pharmacology</subject><subject>Kidney - blood supply</subject><subject>Kidney - physiopathology</subject><subject>Rabbits</subject><subject>Reperfusion Injury - physiopathology</subject><subject>Reperfusion Injury - prevention & control</subject><subject>Selectins - physiology</subject><subject>Time Factors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlZ_grIn0cNq0t3NJicpxS8oeFCh4CFksxOash81ySr992a7RbwJA5nJ-84M8yB0TvANwYTevmKMpzGnBF9xfh3yhMXLAzQmLOcxYSw5RONfywidOLcOJSFpcoxGBNMcszwbo4-Z99B00pu2iVodWWhkFRmnVlAbGVvYgNWd61XTrDu7jb6NX0UOKlDe9J8rUxg_6JGMrCxCGdVtCdUpOtKycnC2fyfo_eH-bf4UL14en-ezRawSSnxMJddSJkSnmqfTBEs2DcGkKjHn0yJJC8ozBQXkTFECeRCKTBLKAFKtME8m6HKYu7HtZwfOizocAFUlG2g7J2gYSzPMgjEbjMq2zlnQYmNNLe1WECx6qmJHVfTIBOdiR1UsQ9_FfkFX1FD-6RowBsPdYIBw5pcBK5wy0CgojQ2cRNmaf1b8AAbeiSA</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Subramanian, Sreekumar</creator><creator>Bowyer, Mark W</creator><creator>Egan, J.Craig</creator><creator>Knolmayer, Thomas J</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model</title><author>Subramanian, Sreekumar ; Bowyer, Mark W ; Egan, J.Craig ; Knolmayer, Thomas J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-6a9faa31f4f94230a82a828acd0992b34b695cebe78c61e7acdb5a168ee4fc093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Blood Urea Nitrogen</topic><topic>Glycyrrhizic Acid - pharmacology</topic><topic>Kidney - blood supply</topic><topic>Kidney - physiopathology</topic><topic>Rabbits</topic><topic>Reperfusion Injury - physiopathology</topic><topic>Reperfusion Injury - prevention & control</topic><topic>Selectins - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Subramanian, Sreekumar</creatorcontrib><creatorcontrib>Bowyer, Mark W</creatorcontrib><creatorcontrib>Egan, J.Craig</creatorcontrib><creatorcontrib>Knolmayer, Thomas J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Subramanian, Sreekumar</au><au>Bowyer, Mark W</au><au>Egan, J.Craig</au><au>Knolmayer, Thomas J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>178</volume><issue>6</issue><spage>573</spage><epage>575</epage><pages>573-575</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Background: The selectin glycoproteins are involved in the pathogenesis of renal ischemia-reperfusion injury. We investigated the ability of glycyrrhizin, a known selectin inhibitor, to attenuate renal ischemia-reperfusion injury.
Methods: Eighteen New Zealand white rabbits underwent midline laparotomy with renal artery cross-clamping. After 30 minutes of reperfusion, group 1 (control, n = 10) animals received a saline infusion, while group 2 (GLY, n = 8) animals received a glycyrrhizin infusion. Renal function was compared between the two groups after 72 hours of reperfusion. A t test was utilized, with α set at P <0.05.
Results: Group 1 and group 2 animals had similar baseline renal function. However, after 72 hours of reperfusion, group 1 animals had a significantly higher mean blood urea nitrogen creatinine ratio than group 2 animals (P <0.01), indicating preserved renal function in rabbits treated with glycyrrhizin.
Conclusions: Selectin blockade using glycyrrhizin attenuates renal ischemia-reperfusion injury when given 30 minutes after the onset of reperfusion in a rabbit model.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10670875</pmid><doi>10.1016/S0002-9610(99)00238-X</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1999-12, Vol.178 (6), p.573-575 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Animals Blood Urea Nitrogen Glycyrrhizic Acid - pharmacology Kidney - blood supply Kidney - physiopathology Rabbits Reperfusion Injury - physiopathology Reperfusion Injury - prevention & control Selectins - physiology Time Factors |
| title | Attenuation of renal ischemia-reperfusion injury with selectin inhibition in a rabbit model |
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