Aminoacyl tRNA synthetases and their connections to disease

Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as aminoacyl tRNA synthetases (AARSs). Surprisingly, the etiology of specific diseases--including cancer, neuronal pathologies, aut...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-08, Vol.105 (32), p.11043-11049
Hauptverfasser:	Park, Sang Gyu, Schimmel, Paul, Kim, Sunghoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acyl-tRNA Synthetases - genetics Amino Acyl-tRNA Synthetases - metabolism Animals Autoimmune diseases Autoimmune Diseases - enzymology Autoimmune Diseases - genetics Autoimmune Diseases - immunology Cancer Catalysis Cytokines Cytokines - genetics Cytokines - immunology Cytokines - metabolism Enzyme Stability - genetics Enzymes Genetic diseases Genetic mutation Genetics Humans Metabolic Diseases - enzymology Metabolic Diseases - genetics Metabolic Diseases - immunology Multienzyme Complexes - genetics Multienzyme Complexes - immunology Multienzyme Complexes - metabolism Mutation Neoplasms - enzymology Neoplasms - genetics Neoplasms - immunology Neovascularization, Pathologic - enzymology Neovascularization, Pathologic - genetics Neovascularization, Pathologic - immunology Nervous system diseases Nervous System Diseases - enzymology Nervous System Diseases - genetics Nervous System Diseases - immunology Perspective Transfer RNA Transfer RNA Aminoacylation - genetics Tumors
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