Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis
In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with system...
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| Veröffentlicht in: | Rheumatology international 2008-09, Vol.28 (11), p.1099-1103 |
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| creator | Sherer, Yaniv Pagnoux, Christian Chironi, Gilles Simon, Alain Guillevin, Loïc Mouthon, Luc Gilburd, Boris Shoenfeld, Yehuda |
| description | In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima–media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE. |
| doi_str_mv | 10.1007/s00296-008-0587-7 |
| format | Article |
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Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima–media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. 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As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoantibodies - blood</subject><subject>Autoimmune diseases</subject><subject>Carotid Artery, Common - pathology</subject><subject>Case-Control Studies</subject><subject>Chaperonin 60 - immunology</subject><subject>Female</subject><subject>Heat-Shock Proteins - immunology</subject><subject>Humans</subject><subject>Immunoglobulin M</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Lupus Erythematosus, Systemic</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><subject>Vasculitis - immunology</subject><subject>Vasculitis - pathology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1q3DAUhUVJaKZpHyCbILroqm4lW5bkZZj-wkA2DWQnZOs6o2RGTnzl0MmmfYe8YZ6kd5iBQCEbCaHvnPtzGDuR4pMUwnxGIcpGF0LYQtTWFOYVm0lVmUJqcXnAZkKasrB0HLE3iNeC3lqL1-xIWkVYo2bsz9yPQ46B-zHDuOEx5bj2T38f1xCi53kZu5sEiB_5EnzmuBy6G35LEogJuU-BD79jiA8Q-OLLgvspD54s2iFEQHLjuMEM69jxBN220kNMV_zeYzetYo74lh32foXwbn8fs4tvX3_NfxSL8-8_52eLoqt0kwtpRGls773RpgKrdV2Wba1745tgoVcqeGWNbW3ooQu9CKamCdtgm8o21ujqmH3Y-VLvdxNgduuIHaxWPsEwodONKpVQksD3_4HXwzQm6s1Zq2RpRK0IkjuIRkIcoXe3I61t3Dgp3DYat4vGUTRuG40zpDndG08tLfdZsc-CgHIHIH2lKxifK7_s-g_X55yE</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Sherer, Yaniv</creator><creator>Pagnoux, Christian</creator><creator>Chironi, Gilles</creator><creator>Simon, Alain</creator><creator>Guillevin, Loïc</creator><creator>Mouthon, Luc</creator><creator>Gilburd, Boris</creator><creator>Shoenfeld, Yehuda</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080901</creationdate><title>Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis</title><author>Sherer, Yaniv ; Pagnoux, Christian ; Chironi, Gilles ; Simon, Alain ; Guillevin, Loïc ; Mouthon, Luc ; Gilburd, Boris ; Shoenfeld, Yehuda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-170278faa7673e866522b56f7a9d8ef44da4878b8dfecdf0d75443bd893898763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Autoantibodies - blood</topic><topic>Autoimmune diseases</topic><topic>Carotid Artery, Common - pathology</topic><topic>Case-Control Studies</topic><topic>Chaperonin 60 - immunology</topic><topic>Female</topic><topic>Heat-Shock Proteins - immunology</topic><topic>Humans</topic><topic>Immunoglobulin M</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Lupus Erythematosus, Systemic</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Proteins</topic><topic>Rheumatology</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><topic>Vasculitis - immunology</topic><topic>Vasculitis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sherer, Yaniv</creatorcontrib><creatorcontrib>Pagnoux, Christian</creatorcontrib><creatorcontrib>Chironi, Gilles</creatorcontrib><creatorcontrib>Simon, Alain</creatorcontrib><creatorcontrib>Guillevin, Loïc</creatorcontrib><creatorcontrib>Mouthon, Luc</creatorcontrib><creatorcontrib>Gilburd, Boris</creatorcontrib><creatorcontrib>Shoenfeld, Yehuda</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sherer, Yaniv</au><au>Pagnoux, Christian</au><au>Chironi, Gilles</au><au>Simon, Alain</au><au>Guillevin, Loïc</au><au>Mouthon, Luc</au><au>Gilburd, Boris</au><au>Shoenfeld, Yehuda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>28</volume><issue>11</issue><spage>1099</spage><epage>1103</epage><pages>1099-1103</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>In this study we evaluate early atherosclerotic changes and determine whether anti-HSP-60, anti-HSP-65 and anti-oxLDL autoantibodies are elevated in systemic necrotizing vasculitis. Thirty-two patients having systemic necrotizing vasculitis were compared with normal controls and patients with systemic lupus erythematosus (SLE). The antibodies against human HSP-60, HSP-65 and oxLDL were measured by antihuman ELISA kit. All patients underwent non-invasive measurements of carotid artery intima–media thickness (IMT). In a comparison between carotid IMT extent between vasculitis patients and SLE, no significant differences were noted. Levels of anti-HSP-60, anti-HSP-65 IgG and anti-oxLDL autoantibodies were similar among patients compared to controls. IgM anti-HSP-60 antibody levels were significantly lower in patients compared to controls and a similar trend was found regarding IgM anti-HSP-65. As a group, patients having various necrotizing vasculitis have similar extent of early atherosclerotic changes regardless of the vasculitis type, and these levels are similar to those found in SLE.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>18443794</pmid><doi>10.1007/s00296-008-0587-7</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0172-8172 |
| ispartof | Rheumatology international, 2008-09, Vol.28 (11), p.1099-1103 |
| issn | 0172-8172 1437-160X |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Aged Autoantibodies - blood Autoimmune diseases Carotid Artery, Common - pathology Case-Control Studies Chaperonin 60 - immunology Female Heat-Shock Proteins - immunology Humans Immunoglobulin M Lipoproteins, LDL - immunology Lupus Erythematosus, Systemic Male Medicine Medicine & Public Health Middle Aged Original Article Proteins Rheumatology Tunica Intima - pathology Tunica Media - pathology Vasculitis - immunology Vasculitis - pathology |
| title | Carotid artery intima–media thickness, heat shock proteins and oxidized LDL autoantibodies in systemic necrotizing vasculitis |
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