The Role of Endothelium-Derived Nitric Oxide in Relaxations to Levcromakalim in the Rat Aorta

The present study was designed to examine the role of basally released nitric oxide in relaxations to an ATP-sensitive K+ channel opener. Whether relaxations to levcromakalim are modulated by endothelial removal or the inhibitors of vasodilator effects of endothelium-derived nitric oxide, were inves...

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Veröffentlicht in:	Japanese Journal of Pharmacology 1999, Vol.81 (4), p.362-366
Hauptverfasser:	Kinoshita, Hiroyuki, Iwahashi, Shizue, Kakutani, Tetsuya, Mizumoto, Kazuhiro, Iranami, Hiroshi, Hatano, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta, Thoracic - drug effects ATP-Binding Cassette Transporters ATP-sensitive K+ channel Benzoates - pharmacology Cromakalim - antagonists & inhibitors Cromakalim - pharmacology Endothelium Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology Glibenclamide Glyburide - pharmacology Guanylate Cyclase - antagonists & inhibitors Hydrazines - pharmacology Imidazoles - pharmacology KATP Channels Male Muscle, Smooth, Vascular - drug effects Nitric oxide Nitric Oxide - physiology Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type III Nitroarginine - pharmacology Potassium Channels - drug effects Potassium Channels, Inwardly Rectifying Rats Rats, Inbred WKY Vasodilator Agents - antagonists & inhibitors Vasodilator Agents - pharmacology
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