Overexpression of telomerase-associated chaperone proteins in prostatic intraepithelial neoplasia and carcinomas

Over 90% of prostate cancers express telomerase activity. In an experimental model, hsp90 and p23, which are necessary for telomerase assembly and function, dramatically increase during tumorigenic conversion. We immunohistochemically analyzed 60 prostate carcinomas, 50 prostatic intraepithelial neo...

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Veröffentlicht in:	Oncology reports 2008-09, Vol.20 (3), p.613-617
Hauptverfasser:	ELMORE, Lynne W, FORSYTHE, Robert, FORSYTHE, Heidi, BRIGHT, A. Taylor, NASIM, Suhail, ENDO, Kanendori, HOLT, Shawn E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - secondary Aged Aged, 80 and over Biological and medical sciences Cell Nucleus - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Immunoenzyme Techniques Intramolecular Oxidoreductases - metabolism Male Medical sciences Middle Aged Neoplasm Staging Nephrology. Urinary tract diseases Prognosis Prostaglandin-E Synthases Prostate - metabolism Prostate - pathology Prostatic Hyperplasia - metabolism Prostatic Hyperplasia - pathology Prostatic Intraepithelial Neoplasia - metabolism Prostatic Intraepithelial Neoplasia - pathology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Telomerase - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland
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