A very strict guideline reduces the number of erythrocyte transfusions in preterm infants
Background and Objectives Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. The objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes. Materials and Methods ...
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| Veröffentlicht in: | Vox sanguinis 2008-08, Vol.95 (2), p.106-111 |
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| creator | Mimica, A. F. M. A. Dos Santos, A. M. N. Da Cunha, D. H. F. Guinsburg, R. Bordin, J. O. Chiba, A. Barros, M. M. O. Kopelman, B. I. |
| description | Background and Objectives Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. The objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes.
Materials and Methods Two prospective cohorts of neonates with gestational age |
| doi_str_mv | 10.1111/j.1423-0410.2008.01072.x |
| format | Article |
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Materials and Methods Two prospective cohorts of neonates with gestational age < 37 weeks and birth weight < 1500 g were studied. Neonates born in Period 1 were submitted to a strict guideline for erythrocyte transfusions. In Period 2, a new stricter protocol was introduced. Infants of both periods were compared regarding number of transfusions and clinical outcome.
Results The median number of transfusions decreased from 2 (1 to 14) in Period 1 to 1 (1–9), P = 0·001, in Period 2. The linear regression multivariate analysis showed that the implementation of the stricter guideline was associated with a reduction in the number of transfusions received by patients by 0·55 (95% confidence interval: –0·08; –1·02) units/patients. Number of apnea episodes, weight at 28 days of life and days of hospital stay were similar in both periods. Intra‐hospital death was lower in Period 2.
Conclusion A very strict guideline reduced the number of erythrocyte transfusions in preterm infants, without threatening their clinical course.</description><identifier>ISSN: 0042-9007</identifier><identifier>EISSN: 1423-0410</identifier><identifier>DOI: 10.1111/j.1423-0410.2008.01072.x</identifier><identifier>PMID: 18544122</identifier><identifier>CODEN: VOSAAD</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>anaemia ; Apnea - epidemiology ; Blood transfusions ; Cerebral Hemorrhage - epidemiology ; Clinical outcomes ; Cohort Studies ; erythrocyte transfusion ; Erythrocyte Transfusion - standards ; Erythrocyte Transfusion - utilization ; Erythrocytes ; Female ; Gestational Age ; Guideline Adherence ; Guidelines ; Hematocrit ; Hospital Mortality ; Humans ; Hypoxia - epidemiology ; Hypoxia - prevention & control ; infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infant, Premature, Diseases - prevention & control ; Infant, Premature, Diseases - therapy ; Infant, Small for Gestational Age ; Infant, Very Low Birth Weight ; Length of Stay - statistics & numerical data ; Male ; Neonatal care ; newborn ; Phlebotomy - adverse effects ; Positive-Pressure Respiration - utilization ; Practice Guidelines as Topic ; premature ; Premature birth ; Prospective Studies ; red blood cells</subject><ispartof>Vox sanguinis, 2008-08, Vol.95 (2), p.106-111</ispartof><rights>2008 The Author(s). Journal compilation © 2008 Blackwell Publishing Ltd</rights><rights>2008 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4322-13784db25d042cff271f1f5e8f13daf65558f5e4cad610e4650735aeba82c1003</citedby><cites>FETCH-LOGICAL-c4322-13784db25d042cff271f1f5e8f13daf65558f5e4cad610e4650735aeba82c1003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1423-0410.2008.01072.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1423-0410.2008.01072.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18544122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mimica, A. F. M. A.</creatorcontrib><creatorcontrib>Dos Santos, A. M. N.</creatorcontrib><creatorcontrib>Da Cunha, D. H. F.</creatorcontrib><creatorcontrib>Guinsburg, R.</creatorcontrib><creatorcontrib>Bordin, J. O.</creatorcontrib><creatorcontrib>Chiba, A.</creatorcontrib><creatorcontrib>Barros, M. M. O.</creatorcontrib><creatorcontrib>Kopelman, B. I.</creatorcontrib><title>A very strict guideline reduces the number of erythrocyte transfusions in preterm infants</title><title>Vox sanguinis</title><addtitle>Vox Sang</addtitle><description>Background and Objectives Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. The objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes.
Materials and Methods Two prospective cohorts of neonates with gestational age < 37 weeks and birth weight < 1500 g were studied. Neonates born in Period 1 were submitted to a strict guideline for erythrocyte transfusions. In Period 2, a new stricter protocol was introduced. Infants of both periods were compared regarding number of transfusions and clinical outcome.
Results The median number of transfusions decreased from 2 (1 to 14) in Period 1 to 1 (1–9), P = 0·001, in Period 2. The linear regression multivariate analysis showed that the implementation of the stricter guideline was associated with a reduction in the number of transfusions received by patients by 0·55 (95% confidence interval: –0·08; –1·02) units/patients. Number of apnea episodes, weight at 28 days of life and days of hospital stay were similar in both periods. Intra‐hospital death was lower in Period 2.
Conclusion A very strict guideline reduced the number of erythrocyte transfusions in preterm infants, without threatening their clinical course.</description><subject>anaemia</subject><subject>Apnea - epidemiology</subject><subject>Blood transfusions</subject><subject>Cerebral Hemorrhage - epidemiology</subject><subject>Clinical outcomes</subject><subject>Cohort Studies</subject><subject>erythrocyte transfusion</subject><subject>Erythrocyte Transfusion - standards</subject><subject>Erythrocyte Transfusion - utilization</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Guideline Adherence</subject><subject>Guidelines</subject><subject>Hematocrit</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Hypoxia - epidemiology</subject><subject>Hypoxia - prevention & control</subject><subject>infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infant, Premature, Diseases - prevention & control</subject><subject>Infant, Premature, Diseases - therapy</subject><subject>Infant, Small for Gestational Age</subject><subject>Infant, Very Low Birth Weight</subject><subject>Length of Stay - statistics & numerical data</subject><subject>Male</subject><subject>Neonatal care</subject><subject>newborn</subject><subject>Phlebotomy - adverse effects</subject><subject>Positive-Pressure Respiration - utilization</subject><subject>Practice Guidelines as Topic</subject><subject>premature</subject><subject>Premature birth</subject><subject>Prospective Studies</subject><subject>red blood cells</subject><issn>0042-9007</issn><issn>1423-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1PGzEQhi1UBGnKX0BWD71t6s9d59ADoi0UITiUtnCyHO-4ON2P1PaW5N_jJRFInOrLjO3nHY0ehDAlM5rPx-WMCsYLIvIDI0TNCCUVm6330OT54w2aECJYMSekOkRvY1ySTDIlD9AhVVIIytgE3Z3gfxA2OKbgbcK_B19D4zvAAerBQsTpHnA3tAsIuHc4o-k-9HaTAKdguuiG6PsuYt_hVYAEoc2tM12K79C-M02Eo12doh9fv9ycnheX12ffTk8uCys4YwXllRL1gsk6L2udYxV11ElQjvLauFJKqfJVWFOXlIAoJam4NLAwillKCJ-iD9u5q9D_HSAm3fpooWlMB_0QdTkXjPF5mcH3r8BlP4Qu76YzIAmTuUyR2kI29DEGcHoVfGvCRlOiR_d6qUfFelSsR_f6yb1e5-jxbv6waKF-Ce5kZ-DTFnjwDWz-e7D-eX07djlfbPM-Jlg_5034o8uKV1L_ujrTqvwubi4-X2jJHwFKeKFq</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Mimica, A. F. M. A.</creator><creator>Dos Santos, A. M. N.</creator><creator>Da Cunha, D. H. F.</creator><creator>Guinsburg, R.</creator><creator>Bordin, J. O.</creator><creator>Chiba, A.</creator><creator>Barros, M. M. O.</creator><creator>Kopelman, B. I.</creator><general>Blackwell Publishing Ltd</general><general>S. Karger AG</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200808</creationdate><title>A very strict guideline reduces the number of erythrocyte transfusions in preterm infants</title><author>Mimica, A. F. M. A. ; Dos Santos, A. M. N. ; Da Cunha, D. H. F. ; Guinsburg, R. ; Bordin, J. O. ; Chiba, A. ; Barros, M. M. O. ; Kopelman, B. 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F. M. A.</creatorcontrib><creatorcontrib>Dos Santos, A. M. N.</creatorcontrib><creatorcontrib>Da Cunha, D. H. F.</creatorcontrib><creatorcontrib>Guinsburg, R.</creatorcontrib><creatorcontrib>Bordin, J. O.</creatorcontrib><creatorcontrib>Chiba, A.</creatorcontrib><creatorcontrib>Barros, M. M. O.</creatorcontrib><creatorcontrib>Kopelman, B. I.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Vox sanguinis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mimica, A. F. M. A.</au><au>Dos Santos, A. M. N.</au><au>Da Cunha, D. H. F.</au><au>Guinsburg, R.</au><au>Bordin, J. O.</au><au>Chiba, A.</au><au>Barros, M. M. O.</au><au>Kopelman, B. I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A very strict guideline reduces the number of erythrocyte transfusions in preterm infants</atitle><jtitle>Vox sanguinis</jtitle><addtitle>Vox Sang</addtitle><date>2008-08</date><risdate>2008</risdate><volume>95</volume><issue>2</issue><spage>106</spage><epage>111</epage><pages>106-111</pages><issn>0042-9007</issn><eissn>1423-0410</eissn><coden>VOSAAD</coden><abstract>Background and Objectives Benefits of adopting restrictive guidelines for erythrocyte transfusions are still controversial. The objective of this study was to verify if a very strict guideline could reduce erythrocyte transfusions in preterm infants without adverse outcomes.
Materials and Methods Two prospective cohorts of neonates with gestational age < 37 weeks and birth weight < 1500 g were studied. Neonates born in Period 1 were submitted to a strict guideline for erythrocyte transfusions. In Period 2, a new stricter protocol was introduced. Infants of both periods were compared regarding number of transfusions and clinical outcome.
Results The median number of transfusions decreased from 2 (1 to 14) in Period 1 to 1 (1–9), P = 0·001, in Period 2. The linear regression multivariate analysis showed that the implementation of the stricter guideline was associated with a reduction in the number of transfusions received by patients by 0·55 (95% confidence interval: –0·08; –1·02) units/patients. Number of apnea episodes, weight at 28 days of life and days of hospital stay were similar in both periods. Intra‐hospital death was lower in Period 2.
Conclusion A very strict guideline reduced the number of erythrocyte transfusions in preterm infants, without threatening their clinical course.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18544122</pmid><doi>10.1111/j.1423-0410.2008.01072.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Journals |
| subjects | anaemia Apnea - epidemiology Blood transfusions Cerebral Hemorrhage - epidemiology Clinical outcomes Cohort Studies erythrocyte transfusion Erythrocyte Transfusion - standards Erythrocyte Transfusion - utilization Erythrocytes Female Gestational Age Guideline Adherence Guidelines Hematocrit Hospital Mortality Humans Hypoxia - epidemiology Hypoxia - prevention & control infant Infant, Newborn Infant, Premature Infant, Premature, Diseases - epidemiology Infant, Premature, Diseases - prevention & control Infant, Premature, Diseases - therapy Infant, Small for Gestational Age Infant, Very Low Birth Weight Length of Stay - statistics & numerical data Male Neonatal care newborn Phlebotomy - adverse effects Positive-Pressure Respiration - utilization Practice Guidelines as Topic premature Premature birth Prospective Studies red blood cells |
| title | A very strict guideline reduces the number of erythrocyte transfusions in preterm infants |
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