Using a Higher Cutoff for the Percentage of HER2+ Cells Decreases Interobserver Variability in the Interpretation of HER2 Immunohistochemical Analysis

The effect of using a 30% cutoff for the proportion of HER2+ cells on the interobserver variability in the interpretation of HER2 immunohistochemical results was evaluated. Immunostained sections from 96 cases of breast carcinoma were reviewed by 10 pathologists and scored as positive (3+) when unif...

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Veröffentlicht in:	American journal of clinical pathology 2008-09, Vol.130 (3), p.425-427
Hauptverfasser:	HAMEED, Omar, ADAMS, Amy L, BAKER, Allyson C, BALMER, Nicole E, BELL, Walter C, BURFORD, Holly N, CHHIENG, David C, JHALA, Nirag C, KLEIN, Michael J, WINOKUR, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - chemistry Breast Neoplasms - pathology Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry - standards Investigative techniques, diagnostic techniques (general aspects) Mammary gland diseases Medical sciences Observer Variation Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptor, ErbB-2 - analysis Reproducibility of Results Tumors
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