Matrix Metalloproteinases and Their Tissue Inhibitors (TIMPs) in Plasmodium falciparum Malaria: Serum Levels of TIMP-1 Are Associated with Disease Severity

Background. Molecular mechanisms involved in the pathogenesis of severe malaria caused by Plasmodium falciparum are not fully understood. Matrix metalloproteinases (MMPs) are enzymes that proteolytically degrade both the extracellular matrix and nonmatrix substances with various functions in the mod...

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Veröffentlicht in:	The Journal of infectious diseases 2008-06, Vol.197 (11), p.1614-1620
Hauptverfasser:	Dietmann, Anelia, Helbok, Raimund, Lackner, Peter, Issifou, Saadou, Lell, Bertrand, Matsiegui, Pierre-Blaise, Reindl, Markus, Schmutzhard, Erich, Kremsner, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood brain barrier Cerebral malaria Child Child, Preschool Enzyme-Linked Immunosorbent Assay Enzymes Falciparum malaria Female Fundamental and applied biological sciences. Psychology Gabon Hospital admissions Human protozoal diseases Humans Infant Infectious diseases Inflammation Life cycle. Host-agent relationship. Pathogenesis Malaria Malaria, Falciparum - immunology Malaria, Falciparum - pathology Male Matrix Metalloproteinases - blood Medical sciences Microbiology Nervous system diseases Parasites Parasitic diseases Pathogenesis Plasmodium falciparum Plasmodium falciparum - immunology Protozoa Protozoal diseases Serum - chemistry Severity of Illness Index Tissue inhibitor of metalloproteinases Tissue Inhibitor of Metalloproteinases - blood
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