Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress

We have previously shown that most melanoma cell lines are insensitive to endoplasmic reticulum (ER) stress-induced apoptosis, and this involves activation of the mitogen-activated protein/extracellular signal-regulated kinase (MEK)/ERK signaling pathway and expression of the apoptosis repressor wit...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2008-08, Vol.68 (16), p.6708-6717
Hauptverfasser:	Jiang, Chen Chen, Lucas, Keryn, Avery-Kiejda, Kelly A, Wade, Margaret, deBock, Charles E, Thorne, Rick F, Allen, John, Hersey, Peter, Zhang, Xu Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - genetics Activating Transcription Factor 6 - metabolism Antiviral Agents - pharmacology Apoptosis - physiology Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Blotting, Western Endoplasmic Reticulum - physiology Endoribonucleases - genetics Endoribonucleases - metabolism Enzyme Inhibitors - pharmacology Flow Cytometry Humans Melanoma - metabolism Melanoma - pathology Membrane Potential, Mitochondrial Myeloid Cell Leukemia Sequence 1 Protein Oxidative Stress Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - pharmacology Signal Transduction Skin Neoplasms - metabolism Skin Neoplasms - pathology Thapsigargin - pharmacology Transcription, Genetic Transfection Tumor Cells, Cultured Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tunicamycin - pharmacology Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!