Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids
Rolling circle amplification (RCA) is an isothermal, enzymatic process mediated by certain DNA polymerases in which long single-stranded (ss) DNA molecules are synthesized on a short circular ssDNA template by using a single DNA primer. A method traditionally used for ultrasensitive DNA detection in...
Gespeichert in:
| Veröffentlicht in: | Angewandte Chemie (International ed.) 2008-08, Vol.47 (34), p.6330-6337 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 6337 |
|---|---|
| container_issue | 34 |
| container_start_page | 6330 |
| container_title | Angewandte Chemie (International ed.) |
| container_volume | 47 |
| creator | Zhao, Weian Ali, M. Monsur Brook, Michael A Li, Yingfu |
| description | Rolling circle amplification (RCA) is an isothermal, enzymatic process mediated by certain DNA polymerases in which long single-stranded (ss) DNA molecules are synthesized on a short circular ssDNA template by using a single DNA primer. A method traditionally used for ultrasensitive DNA detection in areas of genomics and diagnostics, RCA has been used more recently to generate large-scale DNA templates for the creation of periodic nanoassemblies. Various RCA strategies have also been developed for the production of repetitive sequences of DNA aptamers and DNAzymes as detection platforms for small molecules and proteins. In this way, RCA is rapidly becoming a highly versatile DNA amplification tool with wide-ranging applications in genomics, proteomics, diagnosis, biosensing, drug discovery, and nanotechnology. |
| doi_str_mv | 10.1002/anie.200705982 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69421691</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69421691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4052-9e5f8e9f780dd62ba975bb34cd2bc2875fb383cc821ddd83b7c7315b4dd86d023</originalsourceid><addsrcrecordid>eNqFkEtv1DAYRS0Eoi-2LMErdhn8iGOHXRj6ElUqtVRIbCzHdqamHnuIE7Xz7_GQUWHHyr6fzj2LC8BbjBYYIfJRBWcXBCGOWC3IC3CIGcEF5Zy-zP-S0oILhg_AUUo_My8Eql6DAywqgTBGh-DhJnrvwgou3aC9hc16413vtBpdDJ9gs8lxDgm6AFsV4mj1fYg-rrZQBQM_u2hsvu0Y-OjGe3g2hT9JedhOWeo0bLQz6QS86pVP9s3-PQZ3Z6fflhfF1fX55bK5KnSJGClqy3ph654LZExFOlVz1nW01IZ0mgjO-o4KqrUg2BgjaMc1p5h1ZQ6VQYQegw-zdzPEX5NNo1y7pK33Ktg4JVnVJcFVjTO4mEE9xJQG28vN4NZq2EqM5G5euZtXPs-bC-_25qlbW_MX3--ZgXoGHp232__oZNNenv4rL-auS6N9eu6q4UFWnHImv7fn8gv9Wv1oL5BkmX8_872KUq0Gl-TdLUGYIlSTqiSU_ga1h6DJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69421691</pqid></control><display><type>article</type><title>Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhao, Weian ; Ali, M. Monsur ; Brook, Michael A ; Li, Yingfu</creator><creatorcontrib>Zhao, Weian ; Ali, M. Monsur ; Brook, Michael A ; Li, Yingfu</creatorcontrib><description>Rolling circle amplification (RCA) is an isothermal, enzymatic process mediated by certain DNA polymerases in which long single-stranded (ss) DNA molecules are synthesized on a short circular ssDNA template by using a single DNA primer. A method traditionally used for ultrasensitive DNA detection in areas of genomics and diagnostics, RCA has been used more recently to generate large-scale DNA templates for the creation of periodic nanoassemblies. Various RCA strategies have also been developed for the production of repetitive sequences of DNA aptamers and DNAzymes as detection platforms for small molecules and proteins. In this way, RCA is rapidly becoming a highly versatile DNA amplification tool with wide-ranging applications in genomics, proteomics, diagnosis, biosensing, drug discovery, and nanotechnology.</description><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.200705982</identifier><identifier>PMID: 18680110</identifier><language>eng</language><publisher>Weinheim: Wiley-VCH Verlag</publisher><subject>aptamers ; biosensors ; DNA - analysis ; DNA - biosynthesis ; DNA-Directed DNA Polymerase - chemistry ; functional nucleic acids ; nanostructures ; Nanotechnology - methods ; Nucleic Acid Amplification Techniques ; rolling circle amplification</subject><ispartof>Angewandte Chemie (International ed.), 2008-08, Vol.47 (34), p.6330-6337</ispartof><rights>Copyright © 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4052-9e5f8e9f780dd62ba975bb34cd2bc2875fb383cc821ddd83b7c7315b4dd86d023</citedby><cites>FETCH-LOGICAL-c4052-9e5f8e9f780dd62ba975bb34cd2bc2875fb383cc821ddd83b7c7315b4dd86d023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.200705982$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.200705982$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18680110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Weian</creatorcontrib><creatorcontrib>Ali, M. Monsur</creatorcontrib><creatorcontrib>Brook, Michael A</creatorcontrib><creatorcontrib>Li, Yingfu</creatorcontrib><title>Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids</title><title>Angewandte Chemie (International ed.)</title><addtitle>Angewandte Chemie International Edition</addtitle><description>Rolling circle amplification (RCA) is an isothermal, enzymatic process mediated by certain DNA polymerases in which long single-stranded (ss) DNA molecules are synthesized on a short circular ssDNA template by using a single DNA primer. A method traditionally used for ultrasensitive DNA detection in areas of genomics and diagnostics, RCA has been used more recently to generate large-scale DNA templates for the creation of periodic nanoassemblies. Various RCA strategies have also been developed for the production of repetitive sequences of DNA aptamers and DNAzymes as detection platforms for small molecules and proteins. In this way, RCA is rapidly becoming a highly versatile DNA amplification tool with wide-ranging applications in genomics, proteomics, diagnosis, biosensing, drug discovery, and nanotechnology.</description><subject>aptamers</subject><subject>biosensors</subject><subject>DNA - analysis</subject><subject>DNA - biosynthesis</subject><subject>DNA-Directed DNA Polymerase - chemistry</subject><subject>functional nucleic acids</subject><subject>nanostructures</subject><subject>Nanotechnology - methods</subject><subject>Nucleic Acid Amplification Techniques</subject><subject>rolling circle amplification</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtv1DAYRS0Eoi-2LMErdhn8iGOHXRj6ElUqtVRIbCzHdqamHnuIE7Xz7_GQUWHHyr6fzj2LC8BbjBYYIfJRBWcXBCGOWC3IC3CIGcEF5Zy-zP-S0oILhg_AUUo_My8Eql6DAywqgTBGh-DhJnrvwgou3aC9hc16413vtBpdDJ9gs8lxDgm6AFsV4mj1fYg-rrZQBQM_u2hsvu0Y-OjGe3g2hT9JedhOWeo0bLQz6QS86pVP9s3-PQZ3Z6fflhfF1fX55bK5KnSJGClqy3ph654LZExFOlVz1nW01IZ0mgjO-o4KqrUg2BgjaMc1p5h1ZQ6VQYQegw-zdzPEX5NNo1y7pK33Ktg4JVnVJcFVjTO4mEE9xJQG28vN4NZq2EqM5G5euZtXPs-bC-_25qlbW_MX3--ZgXoGHp232__oZNNenv4rL-auS6N9eu6q4UFWnHImv7fn8gv9Wv1oL5BkmX8_872KUq0Gl-TdLUGYIlSTqiSU_ga1h6DJ</recordid><startdate>20080811</startdate><enddate>20080811</enddate><creator>Zhao, Weian</creator><creator>Ali, M. Monsur</creator><creator>Brook, Michael A</creator><creator>Li, Yingfu</creator><general>Wiley-VCH Verlag</general><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080811</creationdate><title>Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids</title><author>Zhao, Weian ; Ali, M. Monsur ; Brook, Michael A ; Li, Yingfu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4052-9e5f8e9f780dd62ba975bb34cd2bc2875fb383cc821ddd83b7c7315b4dd86d023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>aptamers</topic><topic>biosensors</topic><topic>DNA - analysis</topic><topic>DNA - biosynthesis</topic><topic>DNA-Directed DNA Polymerase - chemistry</topic><topic>functional nucleic acids</topic><topic>nanostructures</topic><topic>Nanotechnology - methods</topic><topic>Nucleic Acid Amplification Techniques</topic><topic>rolling circle amplification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Weian</creatorcontrib><creatorcontrib>Ali, M. Monsur</creatorcontrib><creatorcontrib>Brook, Michael A</creatorcontrib><creatorcontrib>Li, Yingfu</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Angewandte Chemie (International ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Weian</au><au>Ali, M. Monsur</au><au>Brook, Michael A</au><au>Li, Yingfu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids</atitle><jtitle>Angewandte Chemie (International ed.)</jtitle><addtitle>Angewandte Chemie International Edition</addtitle><date>2008-08-11</date><risdate>2008</risdate><volume>47</volume><issue>34</issue><spage>6330</spage><epage>6337</epage><pages>6330-6337</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Rolling circle amplification (RCA) is an isothermal, enzymatic process mediated by certain DNA polymerases in which long single-stranded (ss) DNA molecules are synthesized on a short circular ssDNA template by using a single DNA primer. A method traditionally used for ultrasensitive DNA detection in areas of genomics and diagnostics, RCA has been used more recently to generate large-scale DNA templates for the creation of periodic nanoassemblies. Various RCA strategies have also been developed for the production of repetitive sequences of DNA aptamers and DNAzymes as detection platforms for small molecules and proteins. In this way, RCA is rapidly becoming a highly versatile DNA amplification tool with wide-ranging applications in genomics, proteomics, diagnosis, biosensing, drug discovery, and nanotechnology.</abstract><cop>Weinheim</cop><pub>Wiley-VCH Verlag</pub><pmid>18680110</pmid><doi>10.1002/anie.200705982</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1433-7851 |
| ispartof | Angewandte Chemie (International ed.), 2008-08, Vol.47 (34), p.6330-6337 |
| issn | 1433-7851 1521-3773 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69421691 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | aptamers biosensors DNA - analysis DNA - biosynthesis DNA-Directed DNA Polymerase - chemistry functional nucleic acids nanostructures Nanotechnology - methods Nucleic Acid Amplification Techniques rolling circle amplification |
| title | Rolling Circle Amplification: Applications in Nanotechnology and Biodetection with Functional Nucleic Acids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A11%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rolling%20Circle%20Amplification:%20Applications%20in%20Nanotechnology%20and%20Biodetection%20with%20Functional%20Nucleic%20Acids&rft.jtitle=Angewandte%20Chemie%20(International%20ed.)&rft.au=Zhao,%20Weian&rft.date=2008-08-11&rft.volume=47&rft.issue=34&rft.spage=6330&rft.epage=6337&rft.pages=6330-6337&rft.issn=1433-7851&rft.eissn=1521-3773&rft_id=info:doi/10.1002/anie.200705982&rft_dat=%3Cproquest_cross%3E69421691%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69421691&rft_id=info:pmid/18680110&rfr_iscdi=true |