Identification of an epitope on the dengue virus membrane (M) protein defined by cross-protective monoclonal antibodies: design of an improved epitope sequence based on common determinants present in both envelope (E and M) proteins

The protective capacity of monoclonal antibodies (MAbs) generated to the dengue-2 virus envelope (E) and premembrane (prM) proteins was tested in vivo. Two anti-E MAbs, 2C5.1 and 4G2 and two anti-prM MAbs, 2A4.1 and 2H2 provided cross-protection against all four dengue virus serotypes. Overlapping s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of virology 1999-01, Vol.144 (12), p.2313-2330
1. Verfasser:	Falconar, A. K. I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence amino acid sequences Animals Antibodies, Monoclonal - biosynthesis Antibodies, Monoclonal - immunology Antibodies, Viral - immunology Biological and medical sciences Cross Reactions Dengue - immunology Dengue - prevention & control Dengue virus Dengue Virus - chemistry Dengue Virus - growth & development Dengue Virus - immunology E protein Enzyme-Linked Immunosorbent Assay Epitope Mapping epitopes Epitopes - chemistry Epitopes - immunology Fundamental and applied biological sciences. Psychology hybrids Immunization, Passive Immunoblotting M protein Mice Microbiology Molecular Sequence Data monoclonal antibodies Peptides - chemical synthesis Peptides - chemistry Peptides - immunology Protein Precursors - immunology proteins serotypes synthetic peptides Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Envelope Proteins - chemistry Viral Envelope Proteins - immunology Viral Matrix Proteins - chemistry Viral Matrix Proteins - immunology Viral Nonstructural Proteins - immunology Virology viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!