The topological organization of chromosomes 9 and 22 in cell nuclei has a determinative role in the induction of t(9,22) translocations and in the pathogenesis of t(9,22) leukemias

The neighborhood relationships of chromosomes can be of great importance for basic cellular processes such as gene expression or translocation induction. In this study, the topological organization of chromosomes 9 and 22 was investigated in cell nuclei of G0-phase lymphocytes. We found that the ter...

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Veröffentlicht in:	Chromosoma 1999-12, Vol.108 (7), p.426-435
Hauptverfasser:	Kozubek, S, Lukásová, E, Marecková, A, Skalníková, M, Kozubek, M, Bártová, E, Kroha, V, Krahulcová, E, Slotová, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Artificial Gene Fusion Bone marrow Bone Marrow Cells - physiology Cell Line Cell Nucleus - genetics chromosome 22 chromosome 9 Chromosome Aberrations Chromosomes Chromosomes, Human, Pair 22 - chemistry Chromosomes, Human, Pair 22 - ultrastructure Chromosomes, Human, Pair 9 - chemistry Chromosomes, Human, Pair 9 - ultrastructure Genes, abl Humans Image Processing, Computer-Assisted Leukemia - genetics Lymphocytes Lymphocytes - physiology Lymphocytes - radiation effects Male Molecular weight Neutrons Protein-Tyrosine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-bcr Translocation, Genetic
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