Clinical and Immunologic Results of a Phase II Trial of Sequential Imiquimod and Photodynamic Therapy for Vulval Intraepithelial Neoplasia

Purpose: High-risk human papillomavirus (HPV)-associated vulval intraepithelial neoplasia (VIN) is difficult to treat by excision or ablation because of high recurrence rates. Small studies of photodynamic therapy (PDT) and imiquimod treatments have shown some success and function at least in part t...

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Veröffentlicht in:	Clinical cancer research 2008-08, Vol.14 (16), p.5292-5299
Hauptverfasser:	Winters, Ursula, Daayana, Sai, Lear, John T, Tomlinson, Anne E, Elkord, Eyad, Stern, Peter L, Kitchener, Henry C
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Aminoquinolines - administration & dosage Antigens, CD - metabolism Antineoplastic Agents - administration & dosage Carcinoma in Situ - drug therapy Combined Modality Therapy Female Fluorescent Antibody Technique FOXP3 HPV immunity Humans imiquimod Immunohistochemistry Lymphocytes, Tumor-Infiltrating - drug effects Lymphocytes, Tumor-Infiltrating - immunology Middle Aged Photochemotherapy photodynamic therapy T regulatory cells T-Lymphocytes, Regulatory Toll-like receptor vulval intraepithelial neoplasia Vulvar Neoplasms - drug therapy Vulvar Neoplasms - immunology
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