In vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs
The in vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs was appraised using the reference macrodilution method proposed by the National Committee for Clinical Laboratory Standards (NCCLS) for yeasts modified for filamentous fungi. The antifungal drugs amph...
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| Veröffentlicht in: | Medical mycology (Oxford) 1999-12, Vol.37 (6), p.405-409 |
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| container_title | Medical mycology (Oxford) |
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| creator | CALIGIORNE, R. B. RESENDE, M. A. MELILLO, P. H. C. PELUSO, C. P. CARMO, F. H. S. AZEVEDO, V. |
| description | The in vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs was appraised using the reference macrodilution method proposed by the National Committee for Clinical Laboratory Standards (NCCLS) for yeasts modified for filamentous fungi. The antifungal drugs amphotericin B, 5-fluorocytosine, itraconazole and fluconazole were tested against one environmental and 18 clinical isolates. This work amended the macrodilution methods proposed by NCCLS and suggests that a conidial suspension free of hyphae leads to a more reliable assay and provides for better reproducibility. The macrodilution method was performed with 10(4) conidia ml-1. The MIC values ranged from 1.0 to 16.0 micrograms ml-1 for amphotericin B and 3.12 to 25.0 micrograms ml-1 for 5-fluorocytosine. A MIC range of 0.06 to 1.95 micrograms ml-1 was determined for itraconazole while 2.0 to 64.0 micrograms ml-1 was detected for fluconazole. |
| doi_str_mv | 10.1046/j.1365-280X.1999.00245.x |
| format | Article |
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The MIC values ranged from 1.0 to 16.0 micrograms ml-1 for amphotericin B and 3.12 to 25.0 micrograms ml-1 for 5-fluorocytosine. A MIC range of 0.06 to 1.95 micrograms ml-1 was determined for itraconazole while 2.0 to 64.0 micrograms ml-1 was detected for fluconazole.</description><identifier>ISSN: 1369-3786</identifier><identifier>EISSN: 1460-2709</identifier><identifier>DOI: 10.1046/j.1365-280X.1999.00245.x</identifier><identifier>PMID: 10647121</identifier><language>eng</language><publisher>UK: Informa UK Ltd</publisher><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - pharmacology ; Biological and medical sciences ; Chromoblastomycosis - microbiology ; Fluconazole - pharmacology ; Flucytosine - pharmacology ; Fungi - drug effects ; Humans ; Itraconazole - pharmacology ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. 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B.</creatorcontrib><creatorcontrib>RESENDE, M. A.</creatorcontrib><creatorcontrib>MELILLO, P. H. C.</creatorcontrib><creatorcontrib>PELUSO, C. P.</creatorcontrib><creatorcontrib>CARMO, F. H. S.</creatorcontrib><creatorcontrib>AZEVEDO, V.</creatorcontrib><title>In vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs</title><title>Medical mycology (Oxford)</title><addtitle>Med Mycol</addtitle><description>The in vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs was appraised using the reference macrodilution method proposed by the National Committee for Clinical Laboratory Standards (NCCLS) for yeasts modified for filamentous fungi. The antifungal drugs amphotericin B, 5-fluorocytosine, itraconazole and fluconazole were tested against one environmental and 18 clinical isolates. This work amended the macrodilution methods proposed by NCCLS and suggests that a conidial suspension free of hyphae leads to a more reliable assay and provides for better reproducibility. The macrodilution method was performed with 10(4) conidia ml-1. The MIC values ranged from 1.0 to 16.0 micrograms ml-1 for amphotericin B and 3.12 to 25.0 micrograms ml-1 for 5-fluorocytosine. A MIC range of 0.06 to 1.95 micrograms ml-1 was determined for itraconazole while 2.0 to 64.0 micrograms ml-1 was detected for fluconazole.</description><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chromoblastomycosis - microbiology</subject><subject>Fluconazole - pharmacology</subject><subject>Flucytosine - pharmacology</subject><subject>Fungi - drug effects</subject><subject>Humans</subject><subject>Itraconazole - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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This work amended the macrodilution methods proposed by NCCLS and suggests that a conidial suspension free of hyphae leads to a more reliable assay and provides for better reproducibility. The macrodilution method was performed with 10(4) conidia ml-1. The MIC values ranged from 1.0 to 16.0 micrograms ml-1 for amphotericin B and 3.12 to 25.0 micrograms ml-1 for 5-fluorocytosine. A MIC range of 0.06 to 1.95 micrograms ml-1 was determined for itraconazole while 2.0 to 64.0 micrograms ml-1 was detected for fluconazole.</abstract><cop>UK</cop><pub>Informa UK Ltd</pub><pmid>10647121</pmid><doi>10.1046/j.1365-280X.1999.00245.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Access via Taylor & Francis; EZB-FREE-00999 freely available EZB journals |
| subjects | Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - pharmacology Biological and medical sciences Chromoblastomycosis - microbiology Fluconazole - pharmacology Flucytosine - pharmacology Fungi - drug effects Humans Itraconazole - pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments |
| title | In vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs |
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