Ligand binding mode of GABAA receptor-associated protein
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein comp...
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| Veröffentlicht in: | Journal of molecular biology 2008-09, Vol.381 (5), p.1320-1331 |
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| container_issue | 5 |
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| container_title | Journal of molecular biology |
| container_volume | 381 |
| creator | Weiergräber, Oliver H Stangler, Thomas Thielmann, Yvonne Mohrlüder, Jeannine Wiesehan, Katja Willbold, Dieter |
| description | The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein. |
| doi_str_mv | 10.1016/j.jmb.2008.06.086 |
| format | Article |
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| ispartof | Journal of molecular biology, 2008-09, Vol.381 (5), p.1320-1331 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Humans Kinetics Ligands Magnetic Resonance Spectroscopy Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - metabolism Models, Molecular Peptides - metabolism Protein Binding Protein Structure, Secondary Surface Plasmon Resonance |
| title | Ligand binding mode of GABAA receptor-associated protein |
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