Inhibition of initiation of simian virus 40 DNA replication in vitro by the ursodeoxycholic acid and its derivatives

In this study, the effects of the ursodeoxycholic acid (UDCA), and its derivatives, on DNA replication were examined using simian virus (SV40) DNA replication in vitro. We found that UDCA and its derivatives inhibited SV40 DNA replication, and predominantly inhibited the initiation stage of DNA repl...

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Veröffentlicht in:	Cancer letters 1999-11, Vol.146 (2), p.147-153
Hauptverfasser:	Kim, Dong-Kyoo, Lee, Jong-Ryul, Kim, Andre, Lee, Sungeun, Yoo, Mi-Ae, Kim, Kyu-Won, Deuk Kim, Nam, Suh, Hongsuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Antitumor agent Apoptosis Biological and medical sciences Cell cycle Chemotherapy Cytotoxicity Deoxyribonucleic acid DNA DNA biosynthesis DNA replication DNA Replication - drug effects DNA topoisomerase Kinases Medical sciences Pharmacology. Drug treatments Phase transitions Primase Protein A Proteins Replication Replication forks Replication initiation Replication protein A Simian virus 40 Simian virus 40 - drug effects Ursodeoxycholic acid Ursodeoxycholic Acid - analogs & derivatives Ursodeoxycholic Acid - pharmacology Virus Replication - drug effects Viruses
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