Diaphragm inhibition with positive pressure ventilation: quantification of mechanical effects

To quantify any mechanical inhibitory effect of nasal intermittent positive pressure ventilation (IPPV) on inspiratory activity of the diaphragm we ventilated five conscious relaxed subjects on two occasions at respiratory rates similar to quiet breathing (QB) and at three levels of applied pressure (Pappl) — 6, 9 and 12 cmH 2O, each during hypocapnia (P CO 2 allowed to decrease) and eucapnia (CO 2 added to inspired gas). Diaphragm activity was assessed from transdiaphragmatic pressure (esophageal and gastric balloons) and diaphragm EMG (surface electrodes) both integrated with time (∫Pdi·dt and ∫EMGdi·dt, respectively). Neural inspiratory time (Tin) was measured as onset to peak of the ∫EMGdi·dt signal. Relative to QB, ∫Pdi·dt was 50–69% less during eucapnic IPPV 6–12 cmH 2O ( P