Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry
Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical Drosophila mutation, rosy ( ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the techn...
Gespeichert in:
| Veröffentlicht in: | FEBS letters 2008-08, Vol.582 (19), p.2916-2922 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2922 |
|---|---|
| container_issue | 19 |
| container_start_page | 2916 |
| container_title | FEBS letters |
| container_volume | 582 |
| creator | Kamleh, M.A. Hobani, Y. Dow, J.A.T. Watson, D.G. |
| description | Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical
Drosophila mutation,
rosy (
ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected. |
| doi_str_mv | 10.1016/j.febslet.2008.07.029 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69417513</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014579308006200</els_id><sourcerecordid>19481421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5250-746be35a62f0f8ece625114dfb2fbc34be4234259e75fc10bce362887515875e3</originalsourceid><addsrcrecordid>eNqNkc1u1DAURi0EokPhEUBZsUvwf5wVgtKhSEUsgLXlONcdj5xxaiet5u1xNCN1WTa2bJ_72b4HofcENwQT-WnfOOhzgLmhGKsGtw2m3Qu0IaplNeNSvUQbjAmvRduxC_Qm5z0ua0W61-iCKClawdQG2Z8wmz6GOHpbTSk6H_zhroqu-pZijtPOB1Mted0L_n7xQ2V3KY5mjnfJTLtjtY1L8pCqOZlDdjGN1WhyrvIEdi4gzOn4Fr1yJmR4d54v0d_t9Z-rm_r21_cfV19uayuowHXLZQ9MGEkddgosSCoI4YPrqest4z1wyjgVHbTCWYJ7C0xSpVpBRBmAXaKPp9zyj_sF8qxHny2EYA4Ql6xlx0mB2bMg6bginJICihNoSzNyAqen5EeTjppgvWrQe33WoFcNGre6aCh1H84XLP0Iw1PVue8FuDkBjz7A8f9S9fb6K_29Ol2VYoWxLKcl6vMpCkprH4oKna2Hg4XBp-JAD9E_89p_RJyzIw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19481421</pqid></control><display><type>article</type><title>Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Wiley Free Content</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Kamleh, M.A. ; Hobani, Y. ; Dow, J.A.T. ; Watson, D.G.</creator><creatorcontrib>Kamleh, M.A. ; Hobani, Y. ; Dow, J.A.T. ; Watson, D.G.</creatorcontrib><description>Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical
Drosophila mutation,
rosy (
ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2008.07.029</identifier><identifier>PMID: 18657538</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Animals ; ATP-Binding Cassette Transporters - genetics ; Chromatography, Liquid - methods ; Drosophila ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Female ; Fourier Analysis ; Fourier transform mass spectrometry ; Male ; Mass Spectrometry - methods ; Metabolomics ; Mutation</subject><ispartof>FEBS letters, 2008-08, Vol.582 (19), p.2916-2922</ispartof><rights>2008 Federation of European Biochemical Societies</rights><rights>FEBS Letters 582 (2008) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5250-746be35a62f0f8ece625114dfb2fbc34be4234259e75fc10bce362887515875e3</citedby><cites>FETCH-LOGICAL-c5250-746be35a62f0f8ece625114dfb2fbc34be4234259e75fc10bce362887515875e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2008.07.029$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2008.07.029$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,1432,3548,27923,27924,45573,45574,45994,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18657538$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kamleh, M.A.</creatorcontrib><creatorcontrib>Hobani, Y.</creatorcontrib><creatorcontrib>Dow, J.A.T.</creatorcontrib><creatorcontrib>Watson, D.G.</creatorcontrib><title>Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical
Drosophila mutation,
rosy (
ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected.</description><subject>Animals</subject><subject>ATP-Binding Cassette Transporters - genetics</subject><subject>Chromatography, Liquid - methods</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Female</subject><subject>Fourier Analysis</subject><subject>Fourier transform mass spectrometry</subject><subject>Male</subject><subject>Mass Spectrometry - methods</subject><subject>Metabolomics</subject><subject>Mutation</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EokPhEUBZsUvwf5wVgtKhSEUsgLXlONcdj5xxaiet5u1xNCN1WTa2bJ_72b4HofcENwQT-WnfOOhzgLmhGKsGtw2m3Qu0IaplNeNSvUQbjAmvRduxC_Qm5z0ua0W61-iCKClawdQG2Z8wmz6GOHpbTSk6H_zhroqu-pZijtPOB1Mted0L_n7xQ2V3KY5mjnfJTLtjtY1L8pCqOZlDdjGN1WhyrvIEdi4gzOn4Fr1yJmR4d54v0d_t9Z-rm_r21_cfV19uayuowHXLZQ9MGEkddgosSCoI4YPrqest4z1wyjgVHbTCWYJ7C0xSpVpBRBmAXaKPp9zyj_sF8qxHny2EYA4Ql6xlx0mB2bMg6bginJICihNoSzNyAqen5EeTjppgvWrQe33WoFcNGre6aCh1H84XLP0Iw1PVue8FuDkBjz7A8f9S9fb6K_29Ol2VYoWxLKcl6vMpCkprH4oKna2Hg4XBp-JAD9E_89p_RJyzIw</recordid><startdate>20080820</startdate><enddate>20080820</enddate><creator>Kamleh, M.A.</creator><creator>Hobani, Y.</creator><creator>Dow, J.A.T.</creator><creator>Watson, D.G.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080820</creationdate><title>Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry</title><author>Kamleh, M.A. ; Hobani, Y. ; Dow, J.A.T. ; Watson, D.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5250-746be35a62f0f8ece625114dfb2fbc34be4234259e75fc10bce362887515875e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>ATP-Binding Cassette Transporters - genetics</topic><topic>Chromatography, Liquid - methods</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - metabolism</topic><topic>Drosophila Proteins - genetics</topic><topic>Female</topic><topic>Fourier Analysis</topic><topic>Fourier transform mass spectrometry</topic><topic>Male</topic><topic>Mass Spectrometry - methods</topic><topic>Metabolomics</topic><topic>Mutation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kamleh, M.A.</creatorcontrib><creatorcontrib>Hobani, Y.</creatorcontrib><creatorcontrib>Dow, J.A.T.</creatorcontrib><creatorcontrib>Watson, D.G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kamleh, M.A.</au><au>Hobani, Y.</au><au>Dow, J.A.T.</au><au>Watson, D.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2008-08-20</date><risdate>2008</risdate><volume>582</volume><issue>19</issue><spage>2916</spage><epage>2922</epage><pages>2916-2922</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Hydrophilic interaction chromatography (HILIC) interfaced with an Orbitrap Fourier transform mass spectrometer (FT-MS) was used to carry out metabolomic profiling of the classical
Drosophila mutation,
rosy (
ry). This gene encodes a xanthine oxidase/dehydrogenase. In addition to validating the technology by detecting the same changes in xanthine, hypoxanthine, urate and allantoin that have been reported classically, completely unsuspected changes were detected in each of the tryptophan, arginine, pyrimidine and glycerophospholipid metabolism pathways. The rosy mutation thus ramifies far more widely than previously detected.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>18657538</pmid><doi>10.1016/j.febslet.2008.07.029</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 2008-08, Vol.582 (19), p.2916-2922 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69417513 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals ATP-Binding Cassette Transporters - genetics Chromatography, Liquid - methods Drosophila Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Female Fourier Analysis Fourier transform mass spectrometry Male Mass Spectrometry - methods Metabolomics Mutation |
| title | Metabolomic profiling of Drosophila using liquid chromatography Fourier transform mass spectrometry |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T01%3A48%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Metabolomic%20profiling%20of%20Drosophila%20using%20liquid%20chromatography%20Fourier%20transform%20mass%20spectrometry&rft.jtitle=FEBS%20letters&rft.au=Kamleh,%20M.A.&rft.date=2008-08-20&rft.volume=582&rft.issue=19&rft.spage=2916&rft.epage=2922&rft.pages=2916-2922&rft.issn=0014-5793&rft.eissn=1873-3468&rft_id=info:doi/10.1016/j.febslet.2008.07.029&rft_dat=%3Cproquest_cross%3E19481421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19481421&rft_id=info:pmid/18657538&rft_els_id=S0014579308006200&rfr_iscdi=true |