Evasion and exploitation of chemokines by viruses
Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chem...
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| Veröffentlicht in: | Cytokine & growth factor reviews 1999-09, Vol.10 (3), p.219-233 |
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| container_title | Cytokine & growth factor reviews |
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| creator | Lalani, Alshad S. McFadden, Grant |
| description | Chemokines and chemokine receptors play a critical role in the host defense against viruses by mobilizing leukocytes to sites of infection, injury and inflammation. In order to replicate successfully within their host organisms, viruses have devised novel strategies for exploiting or subverting chemokine networks. This review summarizes various mechanisms that are currently known to be used by viruses for modulating chemokine activities including viral homologs of chemokines and chemokine receptors and soluble viral chemokine binding proteins. Insight into these strategies is providing a wealth of information on viral-host interactions, the function of chemokines in host defense and may help to generate novel anti-chemokine agents for treating against viral diseases or inflammatory disorders. |
| doi_str_mv | 10.1016/S1359-6101(99)00018-0 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1359-6101 |
| ispartof | Cytokine & growth factor reviews, 1999-09, Vol.10 (3), p.219-233 |
| issn | 1359-6101 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69416637 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Chemokine Chemokine CCL4 Chemokines - genetics Chemokines - metabolism Chemokines, CXC - genetics Chemokines, CXC - metabolism Herpesviridae - metabolism Herpesvirus Humans Kaposi’s sarcoma Macrophage Inflammatory Proteins - genetics Macrophage Inflammatory Proteins - metabolism Poxviridae - genetics Poxviridae - metabolism Poxviridae - pathogenicity Poxvirus Receptors, Chemokine - genetics Receptors, Chemokine - metabolism Sequence Homology, Amino Acid Viral Proteins - genetics Viral Proteins - metabolism Viroceptor Virokine Viruses - genetics Viruses - metabolism Viruses - pathogenicity |
| title | Evasion and exploitation of chemokines by viruses |
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