[ 123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia

Deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of schizophrenia based on postmortem studies. However, in vivo studies have shown predominantly negative or conflicting results. The goal of this study was to better characterize possi...

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Veröffentlicht in:	Psychiatry research 1999-10, Vol.91 (3), p.163-173
Hauptverfasser:	Verhoeff, Nicolaas Paul L.G, Soares, Jair C, D’Souza, Cyril D, Gil, Roberto, Degen, Kathleen, Abi-Dargham, Anissa, Zoghbi, Sami S, Fujita, Masahiro, Rajeevan, Nallakkandi, Seibyl, John P, Krystal, John H, van Dyck, Christopher H, Charney, Dennis S, Innis, Robert B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Brain - diagnostic imaging Brain - physiopathology Brain Mapping Cerebral Cortex - diagnostic imaging Cerebral Cortex - physiopathology Dominance, Cerebral - physiology Female Flumazenil - analogs & derivatives Frontal Lobe - diagnostic imaging Frontal Lobe - physiopathology GABA Humans Iodine Radioisotopes Male Middle Aged Negative symptoms Positive symptoms Psychiatric Status Rating Scales Psychosis Receptors, GABA-A - physiology Schizophrenia - diagnostic imaging Schizophrenia - physiopathology Thought disorganization Tomography, Emission-Computed, Single-Photon
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