Striatal mechanism of action of corticoliberin on behavior in dogs in conditions of dopamine deficiency
This report describes studies of the interaction of the integrative dopaminergic and corticoliberin systems in the neostriatum during performance of situational food-related conditioned reflexes. Studies were performed in dogs with chemotrodes implanted in the substantia nigra and the head of the ca...
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| Veröffentlicht in: | Neuroscience and behavioral physiology 1999-11, Vol.29 (6), p.665-670 |
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| container_end_page | 670 |
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| container_title | Neuroscience and behavioral physiology |
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| creator | Voilokova, N L Suvorov, N F Rakitskaya, V V Shalyapina, V G |
| description | This report describes studies of the interaction of the integrative dopaminergic and corticoliberin systems in the neostriatum during performance of situational food-related conditioned reflexes. Studies were performed in dogs with chemotrodes implanted in the substantia nigra and the head of the caudate nucleus. 6-Hydroxydopamine was injected into the substantia nigra at a dose of 50 microg, and 10 microg of corticoliberin was injected into the caudate nucleus. Blood cortisol and catecholamine levels were determined. Analysis of the result showed that an interaction takes place in the neostriatum between the corticoliberin and dopaminergic systems, and that in conditions in which dopaminergic structures are excluded, the efficacy of corticoliberin in the performance of behavioral acts decreases by 30-40%, i.e., complete expression of its regulatory role of motor situational conditioned reflexes is lost. |
| doi_str_mv | 10.1007/BF02462481 |
| format | Article |
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Analysis of the result showed that an interaction takes place in the neostriatum between the corticoliberin and dopaminergic systems, and that in conditions in which dopaminergic structures are excluded, the efficacy of corticoliberin in the performance of behavioral acts decreases by 30-40%, i.e., complete expression of its regulatory role of motor situational conditioned reflexes is lost.</description><identifier>ISSN: 0097-0549</identifier><identifier>EISSN: 1573-899X</identifier><identifier>DOI: 10.1007/BF02462481</identifier><identifier>PMID: 10651323</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Behavior, Animal - drug effects ; Caudate Nucleus - physiology ; corticoliberin ; Corticotropin-Releasing Hormone - pharmacology ; Dogs ; Dopamine - deficiency ; Epinephrine - blood ; Hydrocortisone - blood ; Male ; Microinjections ; Neostriatum - drug effects ; Neostriatum - physiology ; Norepinephrine - blood ; Oxidopamine - pharmacology ; Substantia Nigra - physiology ; Sympatholytics - pharmacology ; Time Factors</subject><ispartof>Neuroscience and behavioral physiology, 1999-11, Vol.29 (6), p.665-670</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c229t-5a19effc507df19f0c58f19e19856f7c311b5b0288c4611e317d7e70f817edf73</citedby><cites>FETCH-LOGICAL-c229t-5a19effc507df19f0c58f19e19856f7c311b5b0288c4611e317d7e70f817edf73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10651323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Voilokova, N L</creatorcontrib><creatorcontrib>Suvorov, N F</creatorcontrib><creatorcontrib>Rakitskaya, V V</creatorcontrib><creatorcontrib>Shalyapina, V G</creatorcontrib><title>Striatal mechanism of action of corticoliberin on behavior in dogs in conditions of dopamine deficiency</title><title>Neuroscience and behavioral physiology</title><addtitle>Neurosci Behav Physiol</addtitle><description>This report describes studies of the interaction of the integrative dopaminergic and corticoliberin systems in the neostriatum during performance of situational food-related conditioned reflexes. Studies were performed in dogs with chemotrodes implanted in the substantia nigra and the head of the caudate nucleus. 6-Hydroxydopamine was injected into the substantia nigra at a dose of 50 microg, and 10 microg of corticoliberin was injected into the caudate nucleus. Blood cortisol and catecholamine levels were determined. Analysis of the result showed that an interaction takes place in the neostriatum between the corticoliberin and dopaminergic systems, and that in conditions in which dopaminergic structures are excluded, the efficacy of corticoliberin in the performance of behavioral acts decreases by 30-40%, i.e., complete expression of its regulatory role of motor situational conditioned reflexes is lost.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Caudate Nucleus - physiology</subject><subject>corticoliberin</subject><subject>Corticotropin-Releasing Hormone - pharmacology</subject><subject>Dogs</subject><subject>Dopamine - deficiency</subject><subject>Epinephrine - blood</subject><subject>Hydrocortisone - blood</subject><subject>Male</subject><subject>Microinjections</subject><subject>Neostriatum - drug effects</subject><subject>Neostriatum - physiology</subject><subject>Norepinephrine - blood</subject><subject>Oxidopamine - pharmacology</subject><subject>Substantia Nigra - physiology</subject><subject>Sympatholytics - pharmacology</subject><subject>Time Factors</subject><issn>0097-0549</issn><issn>1573-899X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAUhC0EglJY-AEoEwNSwC-OY3uEigJSJQZAYosc57k1SuJip0j99yRqJdiY7r3TdzccIRdAb4BScXs_p1leZLmEAzIBLlgqlfo4JBNKlUgpz9UJOY3xkw6wkPSYnAAtOLCMTcjytQ9O97pJWjQr3bnYJt4m2vTOd-NlfOid8Y2rMLjB6ZIKV_rb-ZAMb-2XcVTju9qNkThmar_WreswqdE647Az2zNyZHUT8XyvU_I-f3ibPaWLl8fn2d0iNVmm-pRrUGit4VTUFpSlhstBEZTkhRWGAVS8opmUJi8AkIGoBQpqJQisrWBTcrXrXQf_tcHYl62LBptGd-g3sSxUDhyA_wuCyEXGJBvA6x1ogo8xoC3XwbU6bEug5bh_-bv_AF_uWzdVi_UfdDc4-wFB_4Bk</recordid><startdate>199911</startdate><enddate>199911</enddate><creator>Voilokova, N L</creator><creator>Suvorov, N F</creator><creator>Rakitskaya, V V</creator><creator>Shalyapina, V G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7X8</scope></search><sort><creationdate>199911</creationdate><title>Striatal mechanism of action of corticoliberin on behavior in dogs in conditions of dopamine deficiency</title><author>Voilokova, N L ; Suvorov, N F ; Rakitskaya, V V ; Shalyapina, V G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c229t-5a19effc507df19f0c58f19e19856f7c311b5b0288c4611e317d7e70f817edf73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Caudate Nucleus - physiology</topic><topic>corticoliberin</topic><topic>Corticotropin-Releasing Hormone - pharmacology</topic><topic>Dogs</topic><topic>Dopamine - deficiency</topic><topic>Epinephrine - blood</topic><topic>Hydrocortisone - blood</topic><topic>Male</topic><topic>Microinjections</topic><topic>Neostriatum - drug effects</topic><topic>Neostriatum - physiology</topic><topic>Norepinephrine - blood</topic><topic>Oxidopamine - pharmacology</topic><topic>Substantia Nigra - physiology</topic><topic>Sympatholytics - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Voilokova, N L</creatorcontrib><creatorcontrib>Suvorov, N F</creatorcontrib><creatorcontrib>Rakitskaya, V V</creatorcontrib><creatorcontrib>Shalyapina, V G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience and behavioral physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Voilokova, N L</au><au>Suvorov, N F</au><au>Rakitskaya, V V</au><au>Shalyapina, V G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Striatal mechanism of action of corticoliberin on behavior in dogs in conditions of dopamine deficiency</atitle><jtitle>Neuroscience and behavioral physiology</jtitle><addtitle>Neurosci Behav Physiol</addtitle><date>1999-11</date><risdate>1999</risdate><volume>29</volume><issue>6</issue><spage>665</spage><epage>670</epage><pages>665-670</pages><issn>0097-0549</issn><eissn>1573-899X</eissn><abstract>This report describes studies of the interaction of the integrative dopaminergic and corticoliberin systems in the neostriatum during performance of situational food-related conditioned reflexes. 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| source | MEDLINE; SpringerLink Journals |
| subjects | Animals Behavior, Animal - drug effects Caudate Nucleus - physiology corticoliberin Corticotropin-Releasing Hormone - pharmacology Dogs Dopamine - deficiency Epinephrine - blood Hydrocortisone - blood Male Microinjections Neostriatum - drug effects Neostriatum - physiology Norepinephrine - blood Oxidopamine - pharmacology Substantia Nigra - physiology Sympatholytics - pharmacology Time Factors |
| title | Striatal mechanism of action of corticoliberin on behavior in dogs in conditions of dopamine deficiency |
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