Studies of autonomic function in patients with achalasia and nutcracker oesophagus
BACKGROUNDPost-mortem studies in patients with achalasia reveal degenerative changes in the vagus and its dorsal motor nuclei suggesting the possibility of widespread autonomic dysfunction. AIMSTo study a broad range of autonomic function in patients with achalasia and nutcracker oesophagus and in a...
Gespeichert in:
| Veröffentlicht in: | European journal of gastroenterology & hepatology 1999-12, Vol.11 (12), p.1349-1354 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1354 |
|---|---|
| container_issue | 12 |
| container_start_page | 1349 |
| container_title | European journal of gastroenterology & hepatology |
| container_volume | 11 |
| creator | Trudgill, Nigel J Hussain, Faizi N Smith, Lynne F Riley, Stuart A |
| description | BACKGROUNDPost-mortem studies in patients with achalasia reveal degenerative changes in the vagus and its dorsal motor nuclei suggesting the possibility of widespread autonomic dysfunction.
AIMSTo study a broad range of autonomic function in patients with achalasia and nutcracker oesophagus and in asymptomatic volunteers.
SUBJECTPatients with a manometric diagnosis of achalasia and nutcracker oesophagus and age- and sex-matched asymptomatic volunteers.
METHODSSubjects underwent measurement of(1) pupil cycle time estimation; (2) heart rate response to the Valsalva manoeuvre, standing and deep breathing; (3) systolic blood pressure response to standing; (4) diastolic response to sustained handgrip; (5) spectral analysis of heart rate variability; and (6) heart rate and blood pressure during the Valsalva manoeuvre.
RESULTNo significant differences were found between patients with achalasia and asymptomatic volunteers. Patients with nutcracker oesophagus, however, had longer pupil cycle times (1.2 (0.9–1.4) s versus 0.9 (0.8–1.2) s, P= 0.02) and had attenuation of both the rise in the low frequency peak of heart rate variability and the fall in the high frequency peak on standing rise in low frequency peak - patients 26.6 (10.4–52.3)|X% to 422 (155–540)|X%, P = 0.46, volunteers 16.9 (8.4–372) to 47.4 (21.1 – 66.3)|X%, P= 0.03; fall in high frequency peak - periamds 18.1 (0.9–43.3)|X% to 10.1 (0.5–26.6)|X% P = 0.46, volunteers 24.8 (8.5–44.4)|X% to 9.3 (26–35.6)|X% P=0.03), Tine Mine blood pressure during the Valsahra marnoeurne was also attenuated in patients with nutcracker oesophagus compared with asymptomatic volunteers (69 (1.0–9.3)mmHg versus 12.9 (11–23.0) mmHg, P |
| doi_str_mv | 10.1097/00042737-199912000-00002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69413961</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69413961</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3852-d99058000c346492c1810c8ecc003da4f564ca76629e31ad79fa427703bbff0d3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoO4uOPoX5AcxFtrpZNOOkdZ_IIFQXdhb6Emndhxe5IxHwz-e1tn_Lh4KELBU8lbTwihDF4y0OoVAIhecdUxrTXr17ZbC_oHZMOE4t0gR_WQbEAPopOa3V2Sx6V8BWCKM_WIXDKQg1Cab8inz7VNwRWaPMVWU0z7YKlv0daQIg2RHrAGF2uhx1BninbGBUtAinGisVWb0d67TJMr6TDjl1aekAuPS3FPz-eW3L59c3P1vrv--O7D1evrzvJx6LtJaxjGNbXlQgrdWzYysKOzFoBPKPwghUUlZa8dZzgp7XFdWgHf7byHiW_Ji9O9h5y-NVeq2Ydi3bJgdKkVI7VgXEu2guMJtDmVkp03hxz2mL8bBuanT_Pbp_nj0_zyuY4-O7_Rdns3_TN4ErgCz88AFouLzxhtKH-5nvV6jbwl4oQd01JdLvdLO7psZodLnc3_vpP_AIMJjPo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69413961</pqid></control><display><type>article</type><title>Studies of autonomic function in patients with achalasia and nutcracker oesophagus</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Trudgill, Nigel J ; Hussain, Faizi N ; Smith, Lynne F ; Riley, Stuart A</creator><creatorcontrib>Trudgill, Nigel J ; Hussain, Faizi N ; Smith, Lynne F ; Riley, Stuart A</creatorcontrib><description>BACKGROUNDPost-mortem studies in patients with achalasia reveal degenerative changes in the vagus and its dorsal motor nuclei suggesting the possibility of widespread autonomic dysfunction.
AIMSTo study a broad range of autonomic function in patients with achalasia and nutcracker oesophagus and in asymptomatic volunteers.
SUBJECTPatients with a manometric diagnosis of achalasia and nutcracker oesophagus and age- and sex-matched asymptomatic volunteers.
METHODSSubjects underwent measurement of(1) pupil cycle time estimation; (2) heart rate response to the Valsalva manoeuvre, standing and deep breathing; (3) systolic blood pressure response to standing; (4) diastolic response to sustained handgrip; (5) spectral analysis of heart rate variability; and (6) heart rate and blood pressure during the Valsalva manoeuvre.
RESULTNo significant differences were found between patients with achalasia and asymptomatic volunteers. Patients with nutcracker oesophagus, however, had longer pupil cycle times (1.2 (0.9–1.4) s versus 0.9 (0.8–1.2) s, P= 0.02) and had attenuation of both the rise in the low frequency peak of heart rate variability and the fall in the high frequency peak on standing rise in low frequency peak - patients 26.6 (10.4–52.3)|X% to 422 (155–540)|X%, P = 0.46, volunteers 16.9 (8.4–372) to 47.4 (21.1 – 66.3)|X%, P= 0.03; fall in high frequency peak - periamds 18.1 (0.9–43.3)|X% to 10.1 (0.5–26.6)|X% P = 0.46, volunteers 24.8 (8.5–44.4)|X% to 9.3 (26–35.6)|X% P=0.03), Tine Mine blood pressure during the Valsahra marnoeurne was also attenuated in patients with nutcracker oesophagus compared with asymptomatic volunteers (69 (1.0–9.3)mmHg versus 12.9 (11–23.0) mmHg, P<0.01).
CONCLUSIONWhereas tests of cardiovascular anal pupillary autonomic function are normall in patieurisumillIn achalasia, patients with nutcracker oesophagus slaver defects in both parasympathetic and sympathetic function</description><identifier>ISSN: 0954-691X</identifier><identifier>EISSN: 1473-5687</identifier><identifier>DOI: 10.1097/00042737-199912000-00002</identifier><identifier>PMID: 10654793</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Autonomic Nervous System - physiology ; Biological and medical sciences ; Blood Pressure ; Cardiovascular Diseases - physiopathology ; Esophageal Achalasia - diagnosis ; Esophageal Achalasia - physiopathology ; Esophageal Motility Disorders - diagnosis ; Esophageal Motility Disorders - physiopathology ; Esophagus ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Heart Rate ; Humans ; Male ; Malformations ; Medical sciences ; Middle Aged ; Reference Values ; Reflex, Pupillary ; Valsalva Maneuver</subject><ispartof>European journal of gastroenterology & hepatology, 1999-12, Vol.11 (12), p.1349-1354</ispartof><rights>1999 Lippincott Williams & Wilkins, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3852-d99058000c346492c1810c8ecc003da4f564ca76629e31ad79fa427703bbff0d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1212970$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10654793$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trudgill, Nigel J</creatorcontrib><creatorcontrib>Hussain, Faizi N</creatorcontrib><creatorcontrib>Smith, Lynne F</creatorcontrib><creatorcontrib>Riley, Stuart A</creatorcontrib><title>Studies of autonomic function in patients with achalasia and nutcracker oesophagus</title><title>European journal of gastroenterology & hepatology</title><addtitle>Eur J Gastroenterol Hepatol</addtitle><description>BACKGROUNDPost-mortem studies in patients with achalasia reveal degenerative changes in the vagus and its dorsal motor nuclei suggesting the possibility of widespread autonomic dysfunction.
AIMSTo study a broad range of autonomic function in patients with achalasia and nutcracker oesophagus and in asymptomatic volunteers.
SUBJECTPatients with a manometric diagnosis of achalasia and nutcracker oesophagus and age- and sex-matched asymptomatic volunteers.
METHODSSubjects underwent measurement of(1) pupil cycle time estimation; (2) heart rate response to the Valsalva manoeuvre, standing and deep breathing; (3) systolic blood pressure response to standing; (4) diastolic response to sustained handgrip; (5) spectral analysis of heart rate variability; and (6) heart rate and blood pressure during the Valsalva manoeuvre.
RESULTNo significant differences were found between patients with achalasia and asymptomatic volunteers. Patients with nutcracker oesophagus, however, had longer pupil cycle times (1.2 (0.9–1.4) s versus 0.9 (0.8–1.2) s, P= 0.02) and had attenuation of both the rise in the low frequency peak of heart rate variability and the fall in the high frequency peak on standing rise in low frequency peak - patients 26.6 (10.4–52.3)|X% to 422 (155–540)|X%, P = 0.46, volunteers 16.9 (8.4–372) to 47.4 (21.1 – 66.3)|X%, P= 0.03; fall in high frequency peak - periamds 18.1 (0.9–43.3)|X% to 10.1 (0.5–26.6)|X% P = 0.46, volunteers 24.8 (8.5–44.4)|X% to 9.3 (26–35.6)|X% P=0.03), Tine Mine blood pressure during the Valsahra marnoeurne was also attenuated in patients with nutcracker oesophagus compared with asymptomatic volunteers (69 (1.0–9.3)mmHg versus 12.9 (11–23.0) mmHg, P<0.01).
CONCLUSIONWhereas tests of cardiovascular anal pupillary autonomic function are normall in patieurisumillIn achalasia, patients with nutcracker oesophagus slaver defects in both parasympathetic and sympathetic function</description><subject>Adult</subject><subject>Autonomic Nervous System - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Esophageal Achalasia - diagnosis</subject><subject>Esophageal Achalasia - physiopathology</subject><subject>Esophageal Motility Disorders - diagnosis</subject><subject>Esophageal Motility Disorders - physiopathology</subject><subject>Esophagus</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Male</subject><subject>Malformations</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Reference Values</subject><subject>Reflex, Pupillary</subject><subject>Valsalva Maneuver</subject><issn>0954-691X</issn><issn>1473-5687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU2LFDEQhoO4uOPoX5AcxFtrpZNOOkdZ_IIFQXdhb6Emndhxe5IxHwz-e1tn_Lh4KELBU8lbTwihDF4y0OoVAIhecdUxrTXr17ZbC_oHZMOE4t0gR_WQbEAPopOa3V2Sx6V8BWCKM_WIXDKQg1Cab8inz7VNwRWaPMVWU0z7YKlv0daQIg2RHrAGF2uhx1BninbGBUtAinGisVWb0d67TJMr6TDjl1aekAuPS3FPz-eW3L59c3P1vrv--O7D1evrzvJx6LtJaxjGNbXlQgrdWzYysKOzFoBPKPwghUUlZa8dZzgp7XFdWgHf7byHiW_Ji9O9h5y-NVeq2Ydi3bJgdKkVI7VgXEu2guMJtDmVkp03hxz2mL8bBuanT_Pbp_nj0_zyuY4-O7_Rdns3_TN4ErgCz88AFouLzxhtKH-5nvV6jbwl4oQd01JdLvdLO7psZodLnc3_vpP_AIMJjPo</recordid><startdate>199912</startdate><enddate>199912</enddate><creator>Trudgill, Nigel J</creator><creator>Hussain, Faizi N</creator><creator>Smith, Lynne F</creator><creator>Riley, Stuart A</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199912</creationdate><title>Studies of autonomic function in patients with achalasia and nutcracker oesophagus</title><author>Trudgill, Nigel J ; Hussain, Faizi N ; Smith, Lynne F ; Riley, Stuart A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3852-d99058000c346492c1810c8ecc003da4f564ca76629e31ad79fa427703bbff0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Autonomic Nervous System - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Esophageal Achalasia - diagnosis</topic><topic>Esophageal Achalasia - physiopathology</topic><topic>Esophageal Motility Disorders - diagnosis</topic><topic>Esophageal Motility Disorders - physiopathology</topic><topic>Esophagus</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Male</topic><topic>Malformations</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Reference Values</topic><topic>Reflex, Pupillary</topic><topic>Valsalva Maneuver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trudgill, Nigel J</creatorcontrib><creatorcontrib>Hussain, Faizi N</creatorcontrib><creatorcontrib>Smith, Lynne F</creatorcontrib><creatorcontrib>Riley, Stuart A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gastroenterology & hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trudgill, Nigel J</au><au>Hussain, Faizi N</au><au>Smith, Lynne F</au><au>Riley, Stuart A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies of autonomic function in patients with achalasia and nutcracker oesophagus</atitle><jtitle>European journal of gastroenterology & hepatology</jtitle><addtitle>Eur J Gastroenterol Hepatol</addtitle><date>1999-12</date><risdate>1999</risdate><volume>11</volume><issue>12</issue><spage>1349</spage><epage>1354</epage><pages>1349-1354</pages><issn>0954-691X</issn><eissn>1473-5687</eissn><abstract>BACKGROUNDPost-mortem studies in patients with achalasia reveal degenerative changes in the vagus and its dorsal motor nuclei suggesting the possibility of widespread autonomic dysfunction.
AIMSTo study a broad range of autonomic function in patients with achalasia and nutcracker oesophagus and in asymptomatic volunteers.
SUBJECTPatients with a manometric diagnosis of achalasia and nutcracker oesophagus and age- and sex-matched asymptomatic volunteers.
METHODSSubjects underwent measurement of(1) pupil cycle time estimation; (2) heart rate response to the Valsalva manoeuvre, standing and deep breathing; (3) systolic blood pressure response to standing; (4) diastolic response to sustained handgrip; (5) spectral analysis of heart rate variability; and (6) heart rate and blood pressure during the Valsalva manoeuvre.
RESULTNo significant differences were found between patients with achalasia and asymptomatic volunteers. Patients with nutcracker oesophagus, however, had longer pupil cycle times (1.2 (0.9–1.4) s versus 0.9 (0.8–1.2) s, P= 0.02) and had attenuation of both the rise in the low frequency peak of heart rate variability and the fall in the high frequency peak on standing rise in low frequency peak - patients 26.6 (10.4–52.3)|X% to 422 (155–540)|X%, P = 0.46, volunteers 16.9 (8.4–372) to 47.4 (21.1 – 66.3)|X%, P= 0.03; fall in high frequency peak - periamds 18.1 (0.9–43.3)|X% to 10.1 (0.5–26.6)|X% P = 0.46, volunteers 24.8 (8.5–44.4)|X% to 9.3 (26–35.6)|X% P=0.03), Tine Mine blood pressure during the Valsahra marnoeurne was also attenuated in patients with nutcracker oesophagus compared with asymptomatic volunteers (69 (1.0–9.3)mmHg versus 12.9 (11–23.0) mmHg, P<0.01).
CONCLUSIONWhereas tests of cardiovascular anal pupillary autonomic function are normall in patieurisumillIn achalasia, patients with nutcracker oesophagus slaver defects in both parasympathetic and sympathetic function</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10654793</pmid><doi>10.1097/00042737-199912000-00002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-691X |
| ispartof | European journal of gastroenterology & hepatology, 1999-12, Vol.11 (12), p.1349-1354 |
| issn | 0954-691X 1473-5687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69413961 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Autonomic Nervous System - physiology Biological and medical sciences Blood Pressure Cardiovascular Diseases - physiopathology Esophageal Achalasia - diagnosis Esophageal Achalasia - physiopathology Esophageal Motility Disorders - diagnosis Esophageal Motility Disorders - physiopathology Esophagus Female Gastroenterology. Liver. Pancreas. Abdomen Heart Rate Humans Male Malformations Medical sciences Middle Aged Reference Values Reflex, Pupillary Valsalva Maneuver |
| title | Studies of autonomic function in patients with achalasia and nutcracker oesophagus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T06%3A29%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20of%20autonomic%20function%20in%20patients%20with%20achalasia%20and%20nutcracker%20oesophagus&rft.jtitle=European%20journal%20of%20gastroenterology%20&%20hepatology&rft.au=Trudgill,%20Nigel%20J&rft.date=1999-12&rft.volume=11&rft.issue=12&rft.spage=1349&rft.epage=1354&rft.pages=1349-1354&rft.issn=0954-691X&rft.eissn=1473-5687&rft_id=info:doi/10.1097/00042737-199912000-00002&rft_dat=%3Cproquest_cross%3E69413961%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69413961&rft_id=info:pmid/10654793&rfr_iscdi=true |