Phosphatidylcholine-specific phospholipase C, but not phospholipase D, is involved in pemphigus IgG-induced signal transduction

The precise mechanism of the acantholysis after pemphigus IgGs bind to desmoglein (Dsg) 3 and/or Dsg 1 on the cell surface is as yet unknown. We have previously reported that pemphigus IgG (P-IgG) causes a transient increase in intracellular calcium and inositol 1,4,5-trisphosphate concentration, an...

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Veröffentlicht in:	Archives of Dermatological Research 1999-11, Vol.291 (11), p.606-613
Hauptverfasser:	SEISHIMA, M, IWASAKI-BESSHO, Y, ITOH, Y, NOZAWA, Y, AMAGAI, M, KITAJIMA, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bridged-Ring Compounds - pharmacology Bullous diseases of the skin Dermatology Diglycerides - biosynthesis Humans Immunoglobulin G - pharmacology Medical sciences Pemphigus - immunology Phosphatidylinositol Diacylglycerol-Lyase Phospholipase D - physiology Phosphorylcholine - metabolism Protein Kinase C - physiology Signal Transduction Thiones - pharmacology Tumor Cells, Cultured Type C Phospholipases - physiology
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