The relationship between thiamine deficiency and performance of a learning task in rats
We have been investigating the relationship between learning and thiamine. Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior. We taught rats to press a lever to escape from the pain of ele...
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| Veröffentlicht in: | Metabolic brain disease 1999-09, Vol.14 (3), p.137-148 |
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| creator | TERASAWA, M NAKAHARA, T TSUKADA, N SUGAWARA, A ITOKAWA, Y |
| description | We have been investigating the relationship between learning and thiamine. Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior. We taught rats to press a lever to escape from the pain of electrical stimulation by learning to turn a switch off. Then we examined the relationship between learning and the thiamine concentration in various portions of the brain. (1) One group of rats was given a normal diet and another group was given a thiamine-deficient diet which contained half of the amount of thiamine present in the normal diet. We measured the response time required for each rat to react by moving after an electrical impulse was applied, and the running time during which the rat was moving from the starting point to the end point to press a lever. The rats that were fed the thiamine-deficient diet showed a slower response time and a longer running time than the rats fed the normal diet. (2) We divided the rats fed the normal diet into two groups, one group trained to switch off a lever and the other group not trained for such a task. We found that the thiamine concentration in the blood of the rats in the trained group was significantly higher than that in the group without training. |
| doi_str_mv | 10.1023/A:1020654523658 |
| format | Article |
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Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior. We taught rats to press a lever to escape from the pain of electrical stimulation by learning to turn a switch off. Then we examined the relationship between learning and the thiamine concentration in various portions of the brain. (1) One group of rats was given a normal diet and another group was given a thiamine-deficient diet which contained half of the amount of thiamine present in the normal diet. We measured the response time required for each rat to react by moving after an electrical impulse was applied, and the running time during which the rat was moving from the starting point to the end point to press a lever. The rats that were fed the thiamine-deficient diet showed a slower response time and a longer running time than the rats fed the normal diet. (2) We divided the rats fed the normal diet into two groups, one group trained to switch off a lever and the other group not trained for such a task. 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Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior. We taught rats to press a lever to escape from the pain of electrical stimulation by learning to turn a switch off. Then we examined the relationship between learning and the thiamine concentration in various portions of the brain. (1) One group of rats was given a normal diet and another group was given a thiamine-deficient diet which contained half of the amount of thiamine present in the normal diet. We measured the response time required for each rat to react by moving after an electrical impulse was applied, and the running time during which the rat was moving from the starting point to the end point to press a lever. The rats that were fed the thiamine-deficient diet showed a slower response time and a longer running time than the rats fed the normal diet. (2) We divided the rats fed the normal diet into two groups, one group trained to switch off a lever and the other group not trained for such a task. 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NAKAHARA, T ; TSUKADA, N ; SUGAWARA, A ; ITOKAWA, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c340t-e6792007fff3550163f286126313334fb138fe1a3a06a3f6ad5c1b68333bfb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Avoidance Learning - physiology</topic><topic>Behavior, Animal - physiology</topic><topic>Biological and medical sciences</topic><topic>Defense Mechanisms</topic><topic>Electric Stimulation</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)</topic><topic>Periaqueductal Gray - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reaction Time - physiology</topic><topic>Reference Values</topic><topic>thiamine</topic><topic>Thiamine - blood</topic><topic>Thiamine - physiology</topic><topic>Thiamine Deficiency - blood</topic><topic>Thiamine Deficiency - psychology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TERASAWA, M</creatorcontrib><creatorcontrib>NAKAHARA, T</creatorcontrib><creatorcontrib>TSUKADA, N</creatorcontrib><creatorcontrib>SUGAWARA, A</creatorcontrib><creatorcontrib>ITOKAWA, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolic brain disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TERASAWA, M</au><au>NAKAHARA, T</au><au>TSUKADA, N</au><au>SUGAWARA, A</au><au>ITOKAWA, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between thiamine deficiency and performance of a learning task in rats</atitle><jtitle>Metabolic brain disease</jtitle><addtitle>Metab Brain Dis</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>14</volume><issue>3</issue><spage>137</spage><epage>148</epage><pages>137-148</pages><issn>0885-7490</issn><eissn>1573-7365</eissn><coden>MBDIEE</coden><abstract>We have been investigating the relationship between learning and thiamine. Electrical stimulation of mesencephalic periaqueductal gray matter (PAG) is known to have an aversive effect and elicits spontaneous instrumental escape behavior. We taught rats to press a lever to escape from the pain of electrical stimulation by learning to turn a switch off. Then we examined the relationship between learning and the thiamine concentration in various portions of the brain. (1) One group of rats was given a normal diet and another group was given a thiamine-deficient diet which contained half of the amount of thiamine present in the normal diet. We measured the response time required for each rat to react by moving after an electrical impulse was applied, and the running time during which the rat was moving from the starting point to the end point to press a lever. The rats that were fed the thiamine-deficient diet showed a slower response time and a longer running time than the rats fed the normal diet. (2) We divided the rats fed the normal diet into two groups, one group trained to switch off a lever and the other group not trained for such a task. We found that the thiamine concentration in the blood of the rats in the trained group was significantly higher than that in the group without training.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>10646689</pmid><doi>10.1023/A:1020654523658</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Avoidance Learning - physiology Behavior, Animal - physiology Biological and medical sciences Defense Mechanisms Electric Stimulation Female Male Medical sciences Metabolic diseases Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Periaqueductal Gray - physiology Rats Rats, Wistar Reaction Time - physiology Reference Values thiamine Thiamine - blood Thiamine - physiology Thiamine Deficiency - blood Thiamine Deficiency - psychology |
| title | The relationship between thiamine deficiency and performance of a learning task in rats |
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