Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child
BACKGROUND: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary a...
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| Veröffentlicht in: | The American journal of clinical nutrition 2008-08, Vol.88 (2), p.458-464 |
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| creator | Uusitalo, Liisa Kenward, Mike G Virtanen, Suvi M Uusitalo, Ulla Nevalainen, Jaakko Niinistö, Sari Kronberg-Kippilä, Carina Ovaskainen, Marja-Leena Marjamäki, Liisa Simell, Olli Ilonen, Jorma Veijola, Riitta Knip, Mikael |
| description | BACKGROUND: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced β cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >=1 other antibody, overt type 1 diabetes, or both. DESIGN: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. RESULTS: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced β cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. CONCLUSION: High maternal intake of retinol, β-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced β cell autoimmunity in early childhood. |
| doi_str_mv | 10.1093/ajcn/88.2.458 |
| format | Article |
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Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced β cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >=1 other antibody, overt type 1 diabetes, or both. DESIGN: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. RESULTS: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced β cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. CONCLUSION: High maternal intake of retinol, β-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced β cell autoimmunity in early childhood.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/88.2.458</identifier><identifier>PMID: 18689383</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Adult ; antioxidants ; Antioxidants - administration & dosage ; Antioxidants - metabolism ; Autoantibodies - blood ; autoimmunity ; B-lymphocytes ; Biological and medical sciences ; Child ; child nutrition ; Child, Preschool ; children ; Cohort Studies ; Diabetes Mellitus, Type 1 - epidemiology ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 1 - prevention & control ; Feeding. Feeding behavior ; Female ; fetal development ; Finland - epidemiology ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; HLA-DQ Antigens - genetics ; HLA-DQ beta-Chains ; Humans ; Infant ; insulin-dependent diabetes mellitus ; islets of Langerhans ; Islets of Langerhans - immunology ; maternal nutrition ; Maternal Nutritional Physiological Phenomena - physiology ; nutrient intake ; Pregnancy ; Prenatal Exposure Delayed Effects ; Prenatal Nutritional Physiological Phenomena - physiology ; Prospective Studies ; Risk Assessment ; Risk Factors ; trace elements ; Trace Elements - administration & dosage ; Trace Elements - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamins ; Vitamins - administration & dosage ; Vitamins - blood</subject><ispartof>The American journal of clinical nutrition, 2008-08, Vol.88 (2), p.458-464</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-1938fe72b03ea3e81c11397c971354af932e19e5c3559787e35b721b3546e1fb3</citedby><cites>FETCH-LOGICAL-c415t-1938fe72b03ea3e81c11397c971354af932e19e5c3559787e35b721b3546e1fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20590870$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18689383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uusitalo, Liisa</creatorcontrib><creatorcontrib>Kenward, Mike G</creatorcontrib><creatorcontrib>Virtanen, Suvi M</creatorcontrib><creatorcontrib>Uusitalo, Ulla</creatorcontrib><creatorcontrib>Nevalainen, Jaakko</creatorcontrib><creatorcontrib>Niinistö, Sari</creatorcontrib><creatorcontrib>Kronberg-Kippilä, Carina</creatorcontrib><creatorcontrib>Ovaskainen, Marja-Leena</creatorcontrib><creatorcontrib>Marjamäki, Liisa</creatorcontrib><creatorcontrib>Simell, Olli</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Veijola, Riitta</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><title>Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>BACKGROUND: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced β cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >=1 other antibody, overt type 1 diabetes, or both. DESIGN: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. RESULTS: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced β cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. CONCLUSION: High maternal intake of retinol, β-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced β cell autoimmunity in early childhood.</description><subject>Adult</subject><subject>antioxidants</subject><subject>Antioxidants - administration & dosage</subject><subject>Antioxidants - metabolism</subject><subject>Autoantibodies - blood</subject><subject>autoimmunity</subject><subject>B-lymphocytes</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>child nutrition</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Cohort Studies</subject><subject>Diabetes Mellitus, Type 1 - epidemiology</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 1 - prevention & control</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>fetal development</subject><subject>Finland - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>HLA-DQ Antigens - genetics</subject><subject>HLA-DQ beta-Chains</subject><subject>Humans</subject><subject>Infant</subject><subject>insulin-dependent diabetes mellitus</subject><subject>islets of Langerhans</subject><subject>Islets of Langerhans - immunology</subject><subject>maternal nutrition</subject><subject>Maternal Nutritional Physiological Phenomena - physiology</subject><subject>nutrient intake</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Prenatal Nutritional Physiological Phenomena - physiology</subject><subject>Prospective Studies</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>trace elements</subject><subject>Trace Elements - administration & dosage</subject><subject>Trace Elements - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamins</subject><subject>Vitamins - administration & dosage</subject><subject>Vitamins - blood</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1u1DAQB3ALgehSOHIFX-CWrceOY_uIKj4qVeIAPVuOM9m6TZzFTir2tXgQngmnu4Ijp5HGP43G8yfkNbAtMCMu3J2PF1pv-baW-gnZgBG6Epypp2TDGOOVgUaekRc53zEGvNbNc3IGutHFiQ05XMXZ3SOdeuriHKafoSuVPoTZjSHm0uzonJxHigOOGOdMuyWFuKP7hLvooj88mhTy_eOQ7qH0sKO_f1GPw0DdMk9hHJcY5gMNkc63SP1tGLqX5FnvhoyvTvWc3Hz6-P3yS3X99fPV5Yfrytcg52r9T4-Kt0ygE6jBAwijvFEgZO16IziCQemFlEZphUK2ikNbHhuEvhXn5P1x7j5NPxbMsx1DXldzEacl28bUwBSD_0IwEpQQK6yO0Kcp54S93acwunSwwOwail1DsVpbbksoxb85DV7aEbt_-pRCAe9OwGXvhj6VE4b813EmDdOKFff26Ho3WbcrN7c333hZnTHDOW-Y-AMOkp-i</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Uusitalo, Liisa</creator><creator>Kenward, Mike G</creator><creator>Virtanen, Suvi M</creator><creator>Uusitalo, Ulla</creator><creator>Nevalainen, Jaakko</creator><creator>Niinistö, Sari</creator><creator>Kronberg-Kippilä, Carina</creator><creator>Ovaskainen, Marja-Leena</creator><creator>Marjamäki, Liisa</creator><creator>Simell, Olli</creator><creator>Ilonen, Jorma</creator><creator>Veijola, Riitta</creator><creator>Knip, Mikael</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child</title><author>Uusitalo, Liisa ; Kenward, Mike G ; Virtanen, Suvi M ; Uusitalo, Ulla ; Nevalainen, Jaakko ; Niinistö, Sari ; Kronberg-Kippilä, Carina ; Ovaskainen, Marja-Leena ; Marjamäki, Liisa ; Simell, Olli ; Ilonen, Jorma ; Veijola, Riitta ; Knip, Mikael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-1938fe72b03ea3e81c11397c971354af932e19e5c3559787e35b721b3546e1fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>antioxidants</topic><topic>Antioxidants - administration & dosage</topic><topic>Antioxidants - metabolism</topic><topic>Autoantibodies - blood</topic><topic>autoimmunity</topic><topic>B-lymphocytes</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>child nutrition</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Cohort Studies</topic><topic>Diabetes Mellitus, Type 1 - epidemiology</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes Mellitus, Type 1 - prevention & control</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>fetal development</topic><topic>Finland - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>HLA-DQ Antigens - genetics</topic><topic>HLA-DQ beta-Chains</topic><topic>Humans</topic><topic>Infant</topic><topic>insulin-dependent diabetes mellitus</topic><topic>islets of Langerhans</topic><topic>Islets of Langerhans - immunology</topic><topic>maternal nutrition</topic><topic>Maternal Nutritional Physiological Phenomena - physiology</topic><topic>nutrient intake</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Prenatal Nutritional Physiological Phenomena - physiology</topic><topic>Prospective Studies</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>trace elements</topic><topic>Trace Elements - administration & dosage</topic><topic>Trace Elements - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamins</topic><topic>Vitamins - administration & dosage</topic><topic>Vitamins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uusitalo, Liisa</creatorcontrib><creatorcontrib>Kenward, Mike G</creatorcontrib><creatorcontrib>Virtanen, Suvi M</creatorcontrib><creatorcontrib>Uusitalo, Ulla</creatorcontrib><creatorcontrib>Nevalainen, Jaakko</creatorcontrib><creatorcontrib>Niinistö, Sari</creatorcontrib><creatorcontrib>Kronberg-Kippilä, Carina</creatorcontrib><creatorcontrib>Ovaskainen, Marja-Leena</creatorcontrib><creatorcontrib>Marjamäki, Liisa</creatorcontrib><creatorcontrib>Simell, Olli</creatorcontrib><creatorcontrib>Ilonen, Jorma</creatorcontrib><creatorcontrib>Veijola, Riitta</creatorcontrib><creatorcontrib>Knip, Mikael</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uusitalo, Liisa</au><au>Kenward, Mike G</au><au>Virtanen, Suvi M</au><au>Uusitalo, Ulla</au><au>Nevalainen, Jaakko</au><au>Niinistö, Sari</au><au>Kronberg-Kippilä, Carina</au><au>Ovaskainen, Marja-Leena</au><au>Marjamäki, Liisa</au><au>Simell, Olli</au><au>Ilonen, Jorma</au><au>Veijola, Riitta</au><au>Knip, Mikael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>88</volume><issue>2</issue><spage>458</spage><epage>464</epage><pages>458-464</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>BACKGROUND: Type 1 diabetes may have its origins in the fetal period of life. Free radicals were implicated in the cause of type 1 diabetes. It was hypothesized that antioxidant nutrients could protect against type 1 diabetes. OBJECTIVE: We assessed whether high maternal intake of selected dietary antioxidants during pregnancy is associated with a reduced risk of advanced β cell autoimmunity in the child, defined as repeated positivity for islet cell antibodies plus >=1 other antibody, overt type 1 diabetes, or both. DESIGN: The study was carried out as part of the population-based birth cohort of the Type 1 Diabetes Prediction and Prevention Project. The data comprised 4297 children with increased genetic susceptibility to type 1 diabetes, born at the University Hospital of Oulu or Tampere, Finland, between October 1997 and December 2002. The children were monitored for diabetes-associated autoantibodies from samples obtained at 3-12-mo intervals. Maternal antioxidant intake during pregnancy was assessed postnatally with a self-administered food-frequency questionnaire, which contained a question about consumption of dietary supplements. RESULTS: Maternal intake of none of the studied antioxidant nutrients showed association with the risk of advanced β cell autoimmunity in the child. The hazard ratios, indicating the change in risk per a 2-fold increase in the intake of each antioxidant, were nonsignificant and close to 1. CONCLUSION: High maternal intake of retinol, β-carotene, vitamin C, vitamin E, selenium, zinc, or manganese does not protect the child from development of advanced β cell autoimmunity in early childhood.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>18689383</pmid><doi>10.1093/ajcn/88.2.458</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult antioxidants Antioxidants - administration & dosage Antioxidants - metabolism Autoantibodies - blood autoimmunity B-lymphocytes Biological and medical sciences Child child nutrition Child, Preschool children Cohort Studies Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - prevention & control Feeding. Feeding behavior Female fetal development Finland - epidemiology Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease HLA-DQ Antigens - genetics HLA-DQ beta-Chains Humans Infant insulin-dependent diabetes mellitus islets of Langerhans Islets of Langerhans - immunology maternal nutrition Maternal Nutritional Physiological Phenomena - physiology nutrient intake Pregnancy Prenatal Exposure Delayed Effects Prenatal Nutritional Physiological Phenomena - physiology Prospective Studies Risk Assessment Risk Factors trace elements Trace Elements - administration & dosage Trace Elements - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamins Vitamins - administration & dosage Vitamins - blood |
| title | Intake of antioxidant vitamins and trace elements during pregnancy and risk of advanced β cell autoimmunity in the child |
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