Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides
RNA hydrolysis in the presence of HSA proceeds via 2′,3′-cyclophosphate intermediates. Nonenzymatic glycation of HSA decreases protein-mediated oligoribonucleotide cleavage with no influence on the cleavage specificity. Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Non...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2008-08, Vol.18 (16), p.4511-4514 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Gerasimova, Yuliya V. Erchenko, Irina A. Shakirov, Makhmut M. Godovikova, Tatyana S. |
| description | RNA hydrolysis in the presence of HSA proceeds via 2′,3′-cyclophosphate intermediates. Nonenzymatic glycation of HSA decreases protein-mediated oligoribonucleotide cleavage with no influence on the cleavage specificity.
Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to
31P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2′,3′-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed. |
| doi_str_mv | 10.1016/j.bmcl.2008.07.060 |
| format | Article |
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Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to
31P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2′,3′-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.</description><identifier>ISSN: 0960-894X</identifier><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3405</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmcl.2008.07.060</identifier><identifier>PMID: 18674900</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biochemistry - methods ; Chromatography, Ion Exchange - methods ; Glycation ; Human serum albumin ; Humans ; Hydrolysis ; Ligands ; Magnetic Resonance Spectroscopy ; Models, Chemical ; Nucleic Acids - chemistry ; Oligoribonucleotides ; Oligoribonucleotides - chemistry ; Phosphates - chemistry ; Protein Binding ; RNA - chemistry ; RNA-hydrolyzing activity ; Serum Albumin - chemistry ; Serum Albumin - metabolism</subject><ispartof>Bioorganic & medicinal chemistry, 2008-08, Vol.18 (16), p.4511-4514</ispartof><rights>2008 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-6e30c214f797aa8a9898b6f50fa43f4404e0b1f0c842956ae769b962da1896313</citedby><cites>FETCH-LOGICAL-c385t-6e30c214f797aa8a9898b6f50fa43f4404e0b1f0c842956ae769b962da1896313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bmcl.2008.07.060$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18674900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerasimova, Yuliya V.</creatorcontrib><creatorcontrib>Erchenko, Irina A.</creatorcontrib><creatorcontrib>Shakirov, Makhmut M.</creatorcontrib><creatorcontrib>Godovikova, Tatyana S.</creatorcontrib><title>Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem Lett</addtitle><description>RNA hydrolysis in the presence of HSA proceeds via 2′,3′-cyclophosphate intermediates. Nonenzymatic glycation of HSA decreases protein-mediated oligoribonucleotide cleavage with no influence on the cleavage specificity.
Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to
31P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2′,3′-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.</description><subject>Biochemistry - methods</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Glycation</subject><subject>Human serum albumin</subject><subject>Humans</subject><subject>Hydrolysis</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Models, Chemical</subject><subject>Nucleic Acids - chemistry</subject><subject>Oligoribonucleotides</subject><subject>Oligoribonucleotides - chemistry</subject><subject>Phosphates - chemistry</subject><subject>Protein Binding</subject><subject>RNA - chemistry</subject><subject>RNA-hydrolyzing activity</subject><subject>Serum Albumin - chemistry</subject><subject>Serum Albumin - metabolism</subject><issn>0960-894X</issn><issn>0968-0896</issn><issn>1464-3405</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGKFDEQhoMo7rj6Ah4kJ2_dVjqZdAJeZFl1YcGLgreQTlfcDOlkTdIr-_b2OAPe9FRQfP9HUT8hrxn0DJh8d-inxcV-AFA9jD1IeEJ2TEjRcQH7p2QHWkKntPh-QV7UegBgAoR4Ti6YkqPQADuCN6lhsa6FnGj29G5dbKIVy7pQG6d1CYnaNNPQKnUxpOBsjI-0YMQHmxpd8hz8tvyT_xXaHc0x_MglTDmtLmJuYcb6kjzzNlZ8dZ6X5NvH669Xn7vbL59urj7cdo6rfeskcnADE37Uo7XKaqXVJP0evBXci-14hIl5cEoMei8tjlJPWg6zZUpLzvgleXvy3pf8c8XazBKqwxhtwrxWI7VgwAfxX5Bpzjef3MDhBLqSay3ozX0Jiy2PhoE5tmAO5tiCObZgYDRbC1vozdm-TgvOfyPnt2_A-xOA2zMeAhZTXcDkcA4FXTNzDv_y_wa8P5oJ</recordid><startdate>20080815</startdate><enddate>20080815</enddate><creator>Gerasimova, Yuliya V.</creator><creator>Erchenko, Irina A.</creator><creator>Shakirov, Makhmut M.</creator><creator>Godovikova, Tatyana S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080815</creationdate><title>Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides</title><author>Gerasimova, Yuliya V. ; Erchenko, Irina A. ; Shakirov, Makhmut M. ; Godovikova, Tatyana S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-6e30c214f797aa8a9898b6f50fa43f4404e0b1f0c842956ae769b962da1896313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biochemistry - methods</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Glycation</topic><topic>Human serum albumin</topic><topic>Humans</topic><topic>Hydrolysis</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Models, Chemical</topic><topic>Nucleic Acids - chemistry</topic><topic>Oligoribonucleotides</topic><topic>Oligoribonucleotides - chemistry</topic><topic>Phosphates - chemistry</topic><topic>Protein Binding</topic><topic>RNA - chemistry</topic><topic>RNA-hydrolyzing activity</topic><topic>Serum Albumin - chemistry</topic><topic>Serum Albumin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerasimova, Yuliya V.</creatorcontrib><creatorcontrib>Erchenko, Irina A.</creatorcontrib><creatorcontrib>Shakirov, Makhmut M.</creatorcontrib><creatorcontrib>Godovikova, Tatyana S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerasimova, Yuliya V.</au><au>Erchenko, Irina A.</au><au>Shakirov, Makhmut M.</au><au>Godovikova, Tatyana S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>2008-08-15</date><risdate>2008</risdate><volume>18</volume><issue>16</issue><spage>4511</spage><epage>4514</epage><pages>4511-4514</pages><issn>0960-894X</issn><issn>0968-0896</issn><eissn>1464-3405</eissn><eissn>1464-3391</eissn><abstract>RNA hydrolysis in the presence of HSA proceeds via 2′,3′-cyclophosphate intermediates. Nonenzymatic glycation of HSA decreases protein-mediated oligoribonucleotide cleavage with no influence on the cleavage specificity.
Human serum albumin (HSA) was shown to mediate oligoribonucleotide cleavage. Nonenzymatic glycation of HSA decreased the ribonuclease-like activity of the protein. According to
31P NMR data, both native and glycated albumins induced hydrolysis of RNA molecule through 2′,3′-cyclophosphate intermediates. A feasible mechanism of RNA hydrolysis by native albumin and its clinically relevant modification was discussed.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18674900</pmid><doi>10.1016/j.bmcl.2008.07.060</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Biochemistry - methods Chromatography, Ion Exchange - methods Glycation Human serum albumin Humans Hydrolysis Ligands Magnetic Resonance Spectroscopy Models, Chemical Nucleic Acids - chemistry Oligoribonucleotides Oligoribonucleotides - chemistry Phosphates - chemistry Protein Binding RNA - chemistry RNA-hydrolyzing activity Serum Albumin - chemistry Serum Albumin - metabolism |
| title | Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides |
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