Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica
Phyllosticta citricarpa, a leaf spot fungus isolated from the diseased leaves of Citrus medica, displayed the production of taxol, an anticancer drug on M1D and potato dextrose broth medium in culture for the first time. The presence of taxol was confirmed by spectroscopic and chromatographic method...
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| Veröffentlicht in: | Journal of bioscience and bioengineering 2008-07, Vol.106 (1), p.103-106 |
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| container_title | Journal of bioscience and bioengineering |
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| creator | Kumaran, Rangarajulu Senthil Muthumary, Johnpaul Hur, Byung-Ki |
| description | Phyllosticta citricarpa, a leaf spot fungus isolated from the diseased leaves of
Citrus medica, displayed the production of taxol, an anticancer drug on M1D and potato dextrose broth medium in culture for the first time. The presence of taxol was confirmed by spectroscopic and chromatographic methods of analysis. The maximum amount of taxol production was recorded in the fungus grown on M1D medium (265 μg/
l) followed by PDB medium (137 μg/
l). The production rate was increased to 5.3×10
3 fold than that observed in the culture broth of an earlier reported fungus,
Taxomyces andreanae. |
| doi_str_mv | 10.1263/jbb.106.103 |
| format | Article |
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Citrus medica, displayed the production of taxol, an anticancer drug on M1D and potato dextrose broth medium in culture for the first time. The presence of taxol was confirmed by spectroscopic and chromatographic methods of analysis. The maximum amount of taxol production was recorded in the fungus grown on M1D medium (265 μg/
l) followed by PDB medium (137 μg/
l). The production rate was increased to 5.3×10
3 fold than that observed in the culture broth of an earlier reported fungus,
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Citrus medica, displayed the production of taxol, an anticancer drug on M1D and potato dextrose broth medium in culture for the first time. The presence of taxol was confirmed by spectroscopic and chromatographic methods of analysis. The maximum amount of taxol production was recorded in the fungus grown on M1D medium (265 μg/
l) followed by PDB medium (137 μg/
l). The production rate was increased to 5.3×10
3 fold than that observed in the culture broth of an earlier reported fungus,
Taxomyces andreanae.</description><subject>anticancer drug</subject><subject>Ascomycota - classification</subject><subject>Ascomycota - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Citrus - microbiology</subject><subject>Citrus medica</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>leaf spot fungus</subject><subject>Paclitaxel - metabolism</subject><subject>Phyllosticta</subject><subject>Phyllosticta citricarpa</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Leaves - microbiology</subject><subject>Species Specificity</subject><subject>taxol production</subject><issn>1389-1723</issn><issn>1347-4421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFTEQAPBFLPZDT94lIPaiWzPJ5usoD7-g0B6q1zCbl7R57G7WZFfsf9-U91AQwcOQQH4zSWaa5iXQC2CSv9_1_QVQWYM_aU6Ad6rtOgZPH_fatKAYP25OS9lRCooqeNYcg5YGREdPmu83-CsNJOQ0kuu7-2FIZYluQeLikqPDPOM7gmTwGEiZ00LCOt2uhaRAljtPcLqNqcw-j2RTE-rB6Lc17XlzFHAo_sVhPWu-ffp4s_nSXl59_rr5cNk6AXxpFet1b1CgEoJpFagJQikmgXrupUM0gKxTpmMSUbqtMCoApYIx43onFD9rzvd155x-rL4sdozF-WHAyae1WGk6qnW9638QjOBKUFrh67_gLq15qp-w0HXAmeZKVvV2r1xOpWQf7JzjiPneArWPU7F1KnUva_CqXx1qrn3tzx97GEMFbw4Ai8MhZJxcLL8do0JTAF2d2Dtfe_oz-myLi35ytefZu8VuU_znAx4AGzak7g</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Kumaran, Rangarajulu Senthil</creator><creator>Muthumary, Johnpaul</creator><creator>Hur, Byung-Ki</creator><general>Elsevier B.V</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica</title><author>Kumaran, Rangarajulu Senthil ; Muthumary, Johnpaul ; Hur, Byung-Ki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-72b8b9a5a755287f09f5772610e3e6caa91a2479426aa6cd597f1005229cbc573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>anticancer drug</topic><topic>Ascomycota - classification</topic><topic>Ascomycota - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Citrus - microbiology</topic><topic>Citrus medica</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>leaf spot fungus</topic><topic>Paclitaxel - metabolism</topic><topic>Phyllosticta</topic><topic>Phyllosticta citricarpa</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Leaves - microbiology</topic><topic>Species Specificity</topic><topic>taxol production</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumaran, Rangarajulu Senthil</creatorcontrib><creatorcontrib>Muthumary, Johnpaul</creatorcontrib><creatorcontrib>Hur, Byung-Ki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of bioscience and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumaran, Rangarajulu Senthil</au><au>Muthumary, Johnpaul</au><au>Hur, Byung-Ki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica</atitle><jtitle>Journal of bioscience and bioengineering</jtitle><addtitle>J Biosci Bioeng</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>106</volume><issue>1</issue><spage>103</spage><epage>106</epage><pages>103-106</pages><issn>1389-1723</issn><eissn>1347-4421</eissn><coden>JFBIEX</coden><abstract>Phyllosticta citricarpa, a leaf spot fungus isolated from the diseased leaves of
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l) followed by PDB medium (137 μg/
l). The production rate was increased to 5.3×10
3 fold than that observed in the culture broth of an earlier reported fungus,
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| fulltext | fulltext |
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| ispartof | Journal of bioscience and bioengineering, 2008-07, Vol.106 (1), p.103-106 |
| issn | 1389-1723 1347-4421 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | anticancer drug Ascomycota - classification Ascomycota - metabolism Biological and medical sciences Biotechnology Citrus - microbiology Citrus medica Fundamental and applied biological sciences. Psychology leaf spot fungus Paclitaxel - metabolism Phyllosticta Phyllosticta citricarpa Plant Diseases - microbiology Plant Leaves - microbiology Species Specificity taxol production |
| title | Taxol from Phyllosticta citricarpa, a leaf spot fungus of the angiosperm Citrus medica |
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