Redundant DNA methylation in colorectal cancers of Lynch-syndrome patients

Lynch syndrome is an inherited disease resulting predominantly in colorectal cancer (CRC). The crucial cause is DNA mismatch repair (MMR) malfunction that is associated mostly with MLH1 or MSH2 germline mutations. A significant hallmark of repair defects is a high level of instability in microsatell...

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Veröffentlicht in:	Genes chromosomes & cancer 2008-10, Vol.47 (10), p.906-914
Hauptverfasser:	Alemayehu, Aster, Sebova, Katarina, Fridrichova, Ivana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adult Aged Aged, 80 and over Case-Control Studies Colon - metabolism Colorectal Neoplasms - complications Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - genetics DNA - analysis DNA - genetics DNA Methylation DNA, Neoplasm - genetics Epigenesis, Genetic Humans Loss of Heterozygosity Middle Aged Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Nuclear Proteins - genetics Promoter Regions, Genetic - genetics
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