Elevated transglutaminase-induced bonds in PHF tau in Alzheimer's disease

Transglutaminase-induced ε-(γ-glutamyl)lysine bonds covalently cross-link and polymerize peptides into insoluble high molecular weight protein aggregates resistant to degradation and proteolytic digestion. We investigated the hypothesis that excessive deposition of ε-(γ-glutamyl)lysine bonds is a ne...

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Veröffentlicht in:	Brain research 1999-12, Vol.851 (1), p.154-163
Hauptverfasser:	Norlund, Maryam A., M. Lee, John, Zainelli, Gina M., Muma, Nancy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - metabolism Biological and medical sciences Brain - metabolism Cross-linking Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dipeptides - metabolism Humans Medical sciences Middle Aged Neurofibrillary tangle Neurology Paired helical filament paired helical filaments Polymerization tau Proteins - metabolism Transglutaminase Transglutaminases - metabolism
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