Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls
Tau protein is consistently reported to be elevated in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). CSF tau alone, however, is not a clinically useful diagnostic marker due to its relatively low diagnostic specificity. Therefore, efforts are under way to combine tau meas...
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| Veröffentlicht in: | Neuroscience letters 1999-12, Vol.277 (1), p.21-24 |
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| creator | Bürger née Buch, Katharina Padberg, Frank Nolde, Tom Teipel, Stefan J Stübner, Susanne Haslinger, Andreas Schwarz, Markus J Sunderland, Trey Arai, Hiroyuki Rapoport, Stanley I Möller, Hans-Jürgen Hampel, Harald |
| description | Tau protein is consistently reported to be elevated in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). CSF tau alone, however, is not a clinically useful diagnostic marker due to its relatively low diagnostic specificity. Therefore, efforts are under way to combine tau measurements with other criteria in order to improve diagnostic applicability. We investigated whether age could serve as an useful criterion to increase diagnostic accuracy. CSF levels of tau were measured in young old ( |
| doi_str_mv | 10.1016/S0304-3940(99)00845-9 |
| format | Article |
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P<0.001). Based on a previously established cut-off of 260 pg/ml, the discriminative power was higher in the young old than in the old old subjects. Similarly, receiver operating characteristics analysis revealed a statistically significant higher correct classification rate in the young old. Our findings indicate that the discriminative power of CSF tau is higher in the young than in the old old. We suggest that the effect of age should be considered in studies investigating CSF tau as a diagnostic marker for neurodegenerative disorders.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(99)00845-9</identifier><identifier>PMID: 10643888</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Age ; Age Distribution ; Aged ; Aged, 80 and over ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - physiopathology ; Alzheimer’s disease ; Biological and medical sciences ; Cerebrospinal fluid ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis ; Discriminative power ; Female ; Humans ; Major depression ; Male ; Medical sciences ; Middle Aged ; Neurology ; tau Proteins - cerebrospinal fluid ; Tau-protein</subject><ispartof>Neuroscience letters, 1999-12, Vol.277 (1), p.21-24</ispartof><rights>1999 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-88613fd30bcbc7a47b9eda7cef35b8c84212226046659c33badbf1cca980f3fe3</citedby><cites>FETCH-LOGICAL-c473t-88613fd30bcbc7a47b9eda7cef35b8c84212226046659c33badbf1cca980f3fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394099008459$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1197696$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10643888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bürger née Buch, Katharina</creatorcontrib><creatorcontrib>Padberg, Frank</creatorcontrib><creatorcontrib>Nolde, Tom</creatorcontrib><creatorcontrib>Teipel, Stefan J</creatorcontrib><creatorcontrib>Stübner, Susanne</creatorcontrib><creatorcontrib>Haslinger, Andreas</creatorcontrib><creatorcontrib>Schwarz, Markus J</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Rapoport, Stanley I</creatorcontrib><creatorcontrib>Möller, Hans-Jürgen</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><title>Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Tau protein is consistently reported to be elevated in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). CSF tau alone, however, is not a clinically useful diagnostic marker due to its relatively low diagnostic specificity. Therefore, efforts are under way to combine tau measurements with other criteria in order to improve diagnostic applicability. We investigated whether age could serve as an useful criterion to increase diagnostic accuracy. CSF levels of tau were measured in young old (<70 years) and old old (≥70 years) patients with probable AD, elderly patients with major depression (MD), and age-matched healthy controls (HC). In AD patients, CSF tau levels were significantly elevated compared with MD patients and HC (
P<0.001). Based on a previously established cut-off of 260 pg/ml, the discriminative power was higher in the young old than in the old old subjects. Similarly, receiver operating characteristics analysis revealed a statistically significant higher correct classification rate in the young old. Our findings indicate that the discriminative power of CSF tau is higher in the young than in the old old. We suggest that the effect of age should be considered in studies investigating CSF tau as a diagnostic marker for neurodegenerative disorders.</description><subject>Age</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer’s disease</subject><subject>Biological and medical sciences</subject><subject>Cerebrospinal fluid</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis</subject><subject>Discriminative power</subject><subject>Female</subject><subject>Humans</subject><subject>Major depression</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>Tau-protein</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd-O1CAUh4nRuOPqI2i4MLp7UYVCCySbmM3Ef8kmXqjXhMKpg2nLCNTN-DK-qnQ6Ue_2gpDAdw6c34fQU0peUULb158JI7xiipMLpS4Jkbyp1D20oVLUlVCivo82f5Ez9Cil74SQhjb8ITqjpOVMSrlBv7cQoYsh7f1kBtwPs3c4mxnvY8jgJ5x24TZhgzvIGSJ2PtnoxwJnHyZcgEOYp284DA5fXAmCD2BiusR5Z463y_my9oWHKSd86_MOXw-_duBHiC_T0hFMAmzDuDcR3ErYMOUYhvQYPejNkODJaT9HX9-9_bL9UN18ev9xe31TWS5YrqRsKesdI53trDBcdAqcERZ61nTSSl7Tuq5bwtu2UZaxzriup9YaJUnPemDn6MXat8z9Y4aU9VgmhWEwE4Q56bakKFld3wlSwRvOFClgs4K2pJsi9HpfgjPxoCnRi0J9VKgXP1opfVSoVal7dnpg7kZw_1Wtzgrw_ASYZM3QRzNZn_5xVIlWtQV7s2JQYvvpIepkiwILzkewWbvg7_jJH74euwo</recordid><startdate>19991217</startdate><enddate>19991217</enddate><creator>Bürger née Buch, Katharina</creator><creator>Padberg, Frank</creator><creator>Nolde, Tom</creator><creator>Teipel, Stefan J</creator><creator>Stübner, Susanne</creator><creator>Haslinger, Andreas</creator><creator>Schwarz, Markus J</creator><creator>Sunderland, Trey</creator><creator>Arai, Hiroyuki</creator><creator>Rapoport, Stanley I</creator><creator>Möller, Hans-Jürgen</creator><creator>Hampel, Harald</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991217</creationdate><title>Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls</title><author>Bürger née Buch, Katharina ; Padberg, Frank ; Nolde, Tom ; Teipel, Stefan J ; Stübner, Susanne ; Haslinger, Andreas ; Schwarz, Markus J ; Sunderland, Trey ; Arai, Hiroyuki ; Rapoport, Stanley I ; Möller, Hans-Jürgen ; Hampel, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-88613fd30bcbc7a47b9eda7cef35b8c84212226046659c33badbf1cca980f3fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Age</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer’s disease</topic><topic>Biological and medical sciences</topic><topic>Cerebrospinal fluid</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diagnosis</topic><topic>Discriminative power</topic><topic>Female</topic><topic>Humans</topic><topic>Major depression</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>tau Proteins - cerebrospinal fluid</topic><topic>Tau-protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bürger née Buch, Katharina</creatorcontrib><creatorcontrib>Padberg, Frank</creatorcontrib><creatorcontrib>Nolde, Tom</creatorcontrib><creatorcontrib>Teipel, Stefan J</creatorcontrib><creatorcontrib>Stübner, Susanne</creatorcontrib><creatorcontrib>Haslinger, Andreas</creatorcontrib><creatorcontrib>Schwarz, Markus J</creatorcontrib><creatorcontrib>Sunderland, Trey</creatorcontrib><creatorcontrib>Arai, Hiroyuki</creatorcontrib><creatorcontrib>Rapoport, Stanley I</creatorcontrib><creatorcontrib>Möller, Hans-Jürgen</creatorcontrib><creatorcontrib>Hampel, Harald</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bürger née Buch, Katharina</au><au>Padberg, Frank</au><au>Nolde, Tom</au><au>Teipel, Stefan J</au><au>Stübner, Susanne</au><au>Haslinger, Andreas</au><au>Schwarz, Markus J</au><au>Sunderland, Trey</au><au>Arai, Hiroyuki</au><au>Rapoport, Stanley I</au><au>Möller, Hans-Jürgen</au><au>Hampel, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1999-12-17</date><risdate>1999</risdate><volume>277</volume><issue>1</issue><spage>21</spage><epage>24</epage><pages>21-24</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Tau protein is consistently reported to be elevated in cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). CSF tau alone, however, is not a clinically useful diagnostic marker due to its relatively low diagnostic specificity. Therefore, efforts are under way to combine tau measurements with other criteria in order to improve diagnostic applicability. We investigated whether age could serve as an useful criterion to increase diagnostic accuracy. CSF levels of tau were measured in young old (<70 years) and old old (≥70 years) patients with probable AD, elderly patients with major depression (MD), and age-matched healthy controls (HC). In AD patients, CSF tau levels were significantly elevated compared with MD patients and HC (
P<0.001). Based on a previously established cut-off of 260 pg/ml, the discriminative power was higher in the young old than in the old old subjects. Similarly, receiver operating characteristics analysis revealed a statistically significant higher correct classification rate in the young old. Our findings indicate that the discriminative power of CSF tau is higher in the young than in the old old. We suggest that the effect of age should be considered in studies investigating CSF tau as a diagnostic marker for neurodegenerative disorders.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10643888</pmid><doi>10.1016/S0304-3940(99)00845-9</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1999-12, Vol.277 (1), p.21-24 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Age Age Distribution Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - physiopathology Alzheimer’s disease Biological and medical sciences Cerebrospinal fluid Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis Discriminative power Female Humans Major depression Male Medical sciences Middle Aged Neurology tau Proteins - cerebrospinal fluid Tau-protein |
| title | Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls |
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