Downregulation of hepatoma-derived growth factor activates the Bad-mediated apoptotic pathway in human cancer cells

Hepatoma-derived growth factor (HDGF) is highly expressed in human cancer and its expression is correlated with poor prognosis of cancer. The growth factor is known to stimulate cell growth while the underlying mechanism is however not clear. Transfection with HDGF cDNA stimulated while its specific...

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Veröffentlicht in:	Apoptosis (London) 2008-09, Vol.13 (9), p.1135-1147
Hauptverfasser:	Tsang, Tsun Yee, Tang, Wan Yee, Tsang, Wing Pui, Co, Ngai Na, Kong, Siu Kai, Kwok, Tim Tak
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis bcl-Associated Death Protein - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Colforsin - pharmacology Down-Regulation - drug effects Epidermal Growth Factor - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Neoplastic - drug effects Humans Intercellular Signaling Peptides and Proteins - genetics Neoplasms - enzymology Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Oncology Original Paper Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Virology
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