Hanultarin, a cytotoxic lignan as an inhibitor of actin cytoskeleton polymerization from the seeds of Trichosanthes kirilowii

A new lignan derivative, hanultarin, was isolated and structure-determined. It inhibited the polymerization of the actin cycloskeleton and also showed cytotoxic effect against human lung carcinoma A549 and other cell lines. Bioactivity-directed fractionation of extracts from the seeds of Trichosanth...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2008-08, Vol.16 (15), p.7264-7269
Hauptverfasser:	Moon, Surk-Sik, Rahman, Aziz Abdur, Kim, Joo-Young, Kee, Sun-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin cytoskeleton Actin polymerization Actins - metabolism Biological and medical sciences Cell Line Cytoskeleton - drug effects Cytoskeleton - metabolism General pharmacology Hanultarin Humans Keratinocytes - cytology Keratinocytes - drug effects Lignans - chemistry Lignans - pharmacology Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Secoisolariciresinol Seeds - chemistry Structure-Activity Relationship Trichosanthes - chemistry Trichosanthes kirilowii
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