Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study
Background and Objectives: This study is designed to understand the pathophysiology of one of the most serious health problems, chronic tension-type headache (CTTH). Two polymorphic sites in serotonin transporter protein gene attracted much interest. These are: the variable number of tandem repeats...
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creator | Akcali, Aylin Tataroglu, Cengiz Erdal, Emin Aydin, Neriman Pehlivan, Sacide |
description | Background and Objectives: This study is designed to understand the
pathophysiology of one of the most serious health problems, chronic
tension-type headache (CTTH). Two polymorphic sites in serotonin
transporter protein gene attracted much interest. These are: the
variable number of tandem repeats (VNTR) and 5′-flanking promoter
region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR
polymorphisms were investigated in 126 CTTH patients and 138 healthy
control subjects. The patients were being treated with amitripytyline
or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR)
method was used to investigate the polymorphisms in the serotonin
transporter protein gene. Results: There were no statistically
significant results based on the 5-HTTLPR gene alleles, however, STin
2.12/12 genotype and STin 2.12 allele were seen to predominate the
control group. In order to investigate the combined effect of the two
polymorphic loci on the 5-HTT gene expression, samples were separated
into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed
statistically significant frequency in the CTTH group than in the
control group. No significant differences were noticed between the
5-HTTLPR and VNTR haplotype groups and success in treatment.
Conclusion: It is possible to make reliable comparisons and hypothesis
about the homozygous and/or heterozygous presence of S and STin 12/10
alleles which may be in interaction with CTTH. On the other hand, the
presence of homozygous L and STin12 alleles may play a protective role
against CTTH. It is also possible that heterogeneity among diseases
showing the same clinical research will require a lot of effort for
individual identification. |
doi_str_mv | 10.4103/0028-3886.41993 |
format | Article |
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pathophysiology of one of the most serious health problems, chronic
tension-type headache (CTTH). Two polymorphic sites in serotonin
transporter protein gene attracted much interest. These are: the
variable number of tandem repeats (VNTR) and 5′-flanking promoter
region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR
polymorphisms were investigated in 126 CTTH patients and 138 healthy
control subjects. The patients were being treated with amitripytyline
or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR)
method was used to investigate the polymorphisms in the serotonin
transporter protein gene. Results: There were no statistically
significant results based on the 5-HTTLPR gene alleles, however, STin
2.12/12 genotype and STin 2.12 allele were seen to predominate the
control group. In order to investigate the combined effect of the two
polymorphic loci on the 5-HTT gene expression, samples were separated
into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed
statistically significant frequency in the CTTH group than in the
control group. No significant differences were noticed between the
5-HTTLPR and VNTR haplotype groups and success in treatment.
Conclusion: It is possible to make reliable comparisons and hypothesis
about the homozygous and/or heterozygous presence of S and STin 12/10
alleles which may be in interaction with CTTH. On the other hand, the
presence of homozygous L and STin12 alleles may play a protective role
against CTTH. It is also possible that heterogeneity among diseases
showing the same clinical research will require a lot of effort for
individual identification.</description><identifier>ISSN: 0028-3886</identifier><identifier>EISSN: 1998-4022</identifier><identifier>DOI: 10.4103/0028-3886.41993</identifier><identifier>PMID: 18688140</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of the Neurological Society of India</publisher><subject>5-flanking promoter region, chronic tension-type headache, haplotypes, serotonin transporter protein gene, a variable number of tandem repeats ; Adolescent ; Adult ; Analysis of Variance ; Chronic Disease ; Chronic illnesses ; Drugs ; Female ; Gene expression ; Gene Frequency ; Genetic aspects ; Genetic polymorphisms ; Genetic Predisposition to Disease ; Genotype ; Genotype & phenotype ; Headaches ; Health aspects ; Humans ; Male ; Middle Aged ; Polymerase chain reaction ; Polymorphism, Genetic - genetics ; Promoter Regions, Genetic - genetics ; Serotonin Plasma Membrane Transport Proteins - genetics ; Serotonin uptake inhibitors ; Studies ; Tension headache ; Tension-Type Headache - genetics ; Young Adult</subject><ispartof>Neurology India, 2008-04, Vol.56 (2), p.156-160</ispartof><rights>Copyright 2008 Neurology India.</rights><rights>COPYRIGHT 2008 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications Apr-Jun 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b479t-b410b691ea6e834517247e2559dd780d86fb8475eceeb0be7a7d857d09db5d883</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,79426</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18688140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akcali, Aylin</creatorcontrib><creatorcontrib>Tataroglu, Cengiz</creatorcontrib><creatorcontrib>Erdal, Emin</creatorcontrib><creatorcontrib>Aydin, Neriman</creatorcontrib><creatorcontrib>Pehlivan, Sacide</creatorcontrib><title>Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study</title><title>Neurology India</title><addtitle>Neurol India</addtitle><description>Background and Objectives: This study is designed to understand the
pathophysiology of one of the most serious health problems, chronic
tension-type headache (CTTH). Two polymorphic sites in serotonin
transporter protein gene attracted much interest. These are: the
variable number of tandem repeats (VNTR) and 5′-flanking promoter
region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR
polymorphisms were investigated in 126 CTTH patients and 138 healthy
control subjects. The patients were being treated with amitripytyline
or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR)
method was used to investigate the polymorphisms in the serotonin
transporter protein gene. Results: There were no statistically
significant results based on the 5-HTTLPR gene alleles, however, STin
2.12/12 genotype and STin 2.12 allele were seen to predominate the
control group. In order to investigate the combined effect of the two
polymorphic loci on the 5-HTT gene expression, samples were separated
into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed
statistically significant frequency in the CTTH group than in the
control group. No significant differences were noticed between the
5-HTTLPR and VNTR haplotype groups and success in treatment.
Conclusion: It is possible to make reliable comparisons and hypothesis
about the homozygous and/or heterozygous presence of S and STin 12/10
alleles which may be in interaction with CTTH. On the other hand, the
presence of homozygous L and STin12 alleles may play a protective role
against CTTH. It is also possible that heterogeneity among diseases
showing the same clinical research will require a lot of effort for
individual identification.</description><subject>5-flanking promoter region, chronic tension-type headache, haplotypes, serotonin transporter protein gene, a variable number of tandem repeats</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Chronic Disease</subject><subject>Chronic illnesses</subject><subject>Drugs</subject><subject>Female</subject><subject>Gene expression</subject><subject>Gene Frequency</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Headaches</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymerase chain reaction</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Serotonin Plasma Membrane Transport Proteins - genetics</subject><subject>Serotonin uptake inhibitors</subject><subject>Studies</subject><subject>Tension headache</subject><subject>Tension-Type Headache - genetics</subject><subject>Young Adult</subject><issn>0028-3886</issn><issn>1998-4022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkdFv1SAUxonRuLvps2-G-OBbNygUqG83i06TJT6oz4SW05WlhQo0y_3vpd7rlpgFwsmB30dOvg-hd5RcckrYFSG1qphSorRty16gXSmq4qSuX6Ld4-sZOk_pvrSM0fo1OqNKKEU52aHpB8SQg3ce52h8WkLMEPEdeMBLmA5ziMvo0pxwIRaTHfic8IPLI-7HWHQ9zuCTC77KhwXwCMaafoRPeI-XCJObnTfxgFNe7eENejWYKcHbU71Av758_nn9tbr9fvPten9bdVy2uZyUdKKlYAQoxhsqay6hbprWWqmIVWLoFJcN9AAd6UAaaVUjLWlt11il2AX6ePx3ieH3Cinr2aUepsl4CGvSouWkkaIp4If_wPuwRl9m0zUT7eaWLFB1hO7MBNr5IRSn-s2haKbgYXDlek8VlYQzURf-8hm-LAuz658VXB0FfQwpRRj0Et1cXNOU6C1mvQWptyD135iL4v1p7rWbwT7xp1yfZuhcmJyHR6KPzuh_l96VTVSZgv0BHme0Gw</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Akcali, Aylin</creator><creator>Tataroglu, Cengiz</creator><creator>Erdal, Emin</creator><creator>Aydin, Neriman</creator><creator>Pehlivan, Sacide</creator><general>Medknow Publications on behalf of the Neurological Society of India</general><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications & Media Pvt. Ltd</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study</title><author>Akcali, Aylin ; Tataroglu, Cengiz ; Erdal, Emin ; Aydin, Neriman ; Pehlivan, Sacide</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b479t-b410b691ea6e834517247e2559dd780d86fb8475eceeb0be7a7d857d09db5d883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>5-flanking promoter region, chronic tension-type headache, haplotypes, serotonin transporter protein gene, a variable number of tandem repeats</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Chronic Disease</topic><topic>Chronic illnesses</topic><topic>Drugs</topic><topic>Female</topic><topic>Gene expression</topic><topic>Gene Frequency</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Headaches</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymerase chain reaction</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Promoter Regions, Genetic - genetics</topic><topic>Serotonin Plasma Membrane Transport Proteins - genetics</topic><topic>Serotonin uptake inhibitors</topic><topic>Studies</topic><topic>Tension headache</topic><topic>Tension-Type Headache - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akcali, Aylin</creatorcontrib><creatorcontrib>Tataroglu, Cengiz</creatorcontrib><creatorcontrib>Erdal, Emin</creatorcontrib><creatorcontrib>Aydin, Neriman</creatorcontrib><creatorcontrib>Pehlivan, Sacide</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Neurology India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akcali, Aylin</au><au>Tataroglu, Cengiz</au><au>Erdal, Emin</au><au>Aydin, Neriman</au><au>Pehlivan, Sacide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study</atitle><jtitle>Neurology India</jtitle><addtitle>Neurol India</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>56</volume><issue>2</issue><spage>156</spage><epage>160</epage><pages>156-160</pages><issn>0028-3886</issn><eissn>1998-4022</eissn><abstract>Background and Objectives: This study is designed to understand the
pathophysiology of one of the most serious health problems, chronic
tension-type headache (CTTH). Two polymorphic sites in serotonin
transporter protein gene attracted much interest. These are: the
variable number of tandem repeats (VNTR) and 5′-flanking promoter
region (5-HTTLPR). Materials and Methods: VNTR and 5-HTTLPR
polymorphisms were investigated in 126 CTTH patients and 138 healthy
control subjects. The patients were being treated with amitripytyline
or citalopram or sertraline (SSRI). The polymerase chain reaction (PCR)
method was used to investigate the polymorphisms in the serotonin
transporter protein gene. Results: There were no statistically
significant results based on the 5-HTTLPR gene alleles, however, STin
2.12/12 genotype and STin 2.12 allele were seen to predominate the
control group. In order to investigate the combined effect of the two
polymorphic loci on the 5-HTT gene expression, samples were separated
into nine groups. Genotypes (S/S-12/10) and (L/S-12/10) displayed
statistically significant frequency in the CTTH group than in the
control group. No significant differences were noticed between the
5-HTTLPR and VNTR haplotype groups and success in treatment.
Conclusion: It is possible to make reliable comparisons and hypothesis
about the homozygous and/or heterozygous presence of S and STin 12/10
alleles which may be in interaction with CTTH. On the other hand, the
presence of homozygous L and STin12 alleles may play a protective role
against CTTH. It is also possible that heterogeneity among diseases
showing the same clinical research will require a lot of effort for
individual identification.</abstract><cop>India</cop><pub>Medknow Publications on behalf of the Neurological Society of India</pub><pmid>18688140</pmid><doi>10.4103/0028-3886.41993</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals |
subjects | 5-flanking promoter region, chronic tension-type headache, haplotypes, serotonin transporter protein gene, a variable number of tandem repeats Adolescent Adult Analysis of Variance Chronic Disease Chronic illnesses Drugs Female Gene expression Gene Frequency Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease Genotype Genotype & phenotype Headaches Health aspects Humans Male Middle Aged Polymerase chain reaction Polymorphism, Genetic - genetics Promoter Regions, Genetic - genetics Serotonin Plasma Membrane Transport Proteins - genetics Serotonin uptake inhibitors Studies Tension headache Tension-Type Headache - genetics Young Adult |
title | Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study |
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