CaM kinase II and protein kinase C activations mediate enhancement of long-term potentiation by nefiracetam in the rat hippocampal CA1 region

Nefiracetam is a pyrrolidine-related nootropic drug exhibiting various pharmacological actions such as cognitive-enhancing effect. We previously showed that nefiracetam potentiates NMDA-induced currents in cultured rat cortical neurons. To address questions whether nefiracetam affects NMDA receptor-...

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Veröffentlicht in:	Journal of neurochemistry 2008-08, Vol.106 (3), p.1092-1103
Hauptverfasser:	Moriguchi, Shigeki, Shioda, Norifumi, Han, Feng, Narahashi, Toshio, Fukunaga, Kohji
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer disease Alzheimer’s disease Animals Biochemistry Biological and medical sciences Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism calcium/calmodulin-dependent protein kinase II Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dose-Response Relationship, Drug Enzyme Activation - drug effects Enzyme Activation - physiology Hippocampus - drug effects Hippocampus - enzymology long-term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Medical sciences N-methyl- d-aspartate acid nefiracetam Neurology Neurotransmitters Organic mental disorders. Neuropsychology Pharmacology protein kinase C Protein Kinase C - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Pyrrolidinones - pharmacology Rats Rats, Wistar Rodents
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