Exploring the substrate specificity of OxyB, a phenol coupling P450 enzyme involved in vancomycin biosynthesis

OxyB is a cytochrome P450 enzyme that catalyzes the first oxidative phenol coupling reaction during vancomycin biosynthesis. The preferred substrate is a linear peptide linked as a C-terminal thioester to a peptide carrier protein (PCP) domain of the glycopeptide antibiotic non-ribosomal peptide syn...

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Veröffentlicht in:	Organic & biomolecular chemistry 2008-08, Vol.6 (16), p.2861-2867
Hauptverfasser:	Woithe, Katharina, Geib, Nina, Meyer, Odile, Wörtz, Tanja, Zerbe, Katja, Robinson, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cytochrome P-450 Enzyme System - chemistry Cytochrome P-450 Enzyme System - metabolism Molecular Structure Phenols - chemistry Receptors, Steroid - chemistry Receptors, Steroid - metabolism Substrate Specificity Vancomycin - biosynthesis
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