Determination of Free Growth Hormone

Context: Approximately 50% of circulating GH is bound to the high-affinity GH-binding protein (GHBP), which is known to affect the pharmacokinetics, bioactivity, and quantitative determination of GH. Nevertheless, the presence of GHBP is rarely taken into account in the clinical use of GH measuremen...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2008-08, Vol.93 (8), p.3008-3014
Hauptverfasser:	Frystyk, Jan, Andreasen, Caroline Marie, Fisker, Sanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Area Under Curve Biological activity Biological and medical sciences Carrier Proteins - pharmacology Centrifugation Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Growth hormones Human Growth Hormone - blood Humans Immunological tolerance Insulin Resistance Male Medical sciences Middle Aged Monoclonal antibodies Pharmacokinetics Ultrafiltration Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
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