Bone metastasis in hepatocellular carcinoma: Need for reappraisal of treatment
Bone is an uncommon site of metastasis in patients with hepatocellular carcinoma (HCC), and often overlooked. We report two cases that had isolated bone metastasis; one of them had prolonged disease-free survival. The present series, along with the literature review, reinforces the idea that HCC sho...
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| Veröffentlicht in: | Journal of cancer research and therapeutics 2008-04, Vol.4 (2), p.93-94 |
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| creator | Attili, V. Satya Suresh Babu, K. Govind Lokanatha, D Bapsy, P.P Ramachandra, C Rajshekar, H |
| description | Bone is an uncommon site of metastasis in patients with hepatocellular
carcinoma (HCC), and often overlooked. We report two cases that had
isolated bone metastasis; one of them had prolonged disease-free
survival. The present series, along with the literature review,
reinforces the idea that HCC should be considered in the differential
diagnoses in patients presenting with metastases in bone. The presence
of isolated bone metastases need not necessarily indicate poor
prognosis, and all such patients need to be offered chemotherapy and at
least one of the bone-directed therapies (either local radiation in
cases of localized disease or bisphosphonates in the presence of
extensive disease) as they may have a better outcome with therapy. |
| doi_str_mv | 10.4103/0973-1482.42257 |
| format | Article |
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carcinoma (HCC), and often overlooked. We report two cases that had
isolated bone metastasis; one of them had prolonged disease-free
survival. The present series, along with the literature review,
reinforces the idea that HCC should be considered in the differential
diagnoses in patients presenting with metastases in bone. The presence
of isolated bone metastases need not necessarily indicate poor
prognosis, and all such patients need to be offered chemotherapy and at
least one of the bone-directed therapies (either local radiation in
cases of localized disease or bisphosphonates in the presence of
extensive disease) as they may have a better outcome with therapy.</description><identifier>ISSN: 0973-1482</identifier><identifier>EISSN: 1998-4138</identifier><identifier>DOI: 10.4103/0973-1482.42257</identifier><identifier>PMID: 18688127</identifier><language>eng</language><publisher>India: Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)</publisher><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Blood clots ; Bone cancer ; Bone metastasis, hepatocellular carcinoma ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - drug therapy ; Bone Neoplasms - secondary ; Brain Neoplasms - diagnosis ; Brain Neoplasms - secondary ; Cancer ; Carcinoma, Hepatocellular - drug therapy ; Carcinoma, Hepatocellular - pathology ; Care and treatment ; Case studies ; Cisplatin - administration & dosage ; Diagnosis ; Diphosphonates - administration & dosage ; Doxorubicin - administration & dosage ; Fatal Outcome ; Female ; Hepatoma ; Histology ; Humans ; Imidazoles - administration & dosage ; Liver Neoplasms - drug therapy ; Liver Neoplasms - pathology ; Male ; Medical treatment ; Middle Aged ; Neoplasm Staging ; Palliative Care ; Patient outcomes ; Radiography, Thoracic ; Risk factors</subject><ispartof>Journal of cancer research and therapeutics, 2008-04, Vol.4 (2), p.93-94</ispartof><rights>Copyright 2008 Journal of Cancer Research and Therapeutics.</rights><rights>COPYRIGHT 2008 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Apr 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-13823ab0e95b1c327ca49e988391926071e4621debc55dcfac1a8577ea72a9af3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934,79436</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18688127$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Attili, V. Satya Suresh</creatorcontrib><creatorcontrib>Babu, K. Govind</creatorcontrib><creatorcontrib>Lokanatha, D</creatorcontrib><creatorcontrib>Bapsy, P.P</creatorcontrib><creatorcontrib>Ramachandra, C</creatorcontrib><creatorcontrib>Rajshekar, H</creatorcontrib><title>Bone metastasis in hepatocellular carcinoma: Need for reappraisal of treatment</title><title>Journal of cancer research and therapeutics</title><addtitle>J Cancer Res Ther</addtitle><description>Bone is an uncommon site of metastasis in patients with hepatocellular
carcinoma (HCC), and often overlooked. We report two cases that had
isolated bone metastasis; one of them had prolonged disease-free
survival. The present series, along with the literature review,
reinforces the idea that HCC should be considered in the differential
diagnoses in patients presenting with metastases in bone. The presence
of isolated bone metastases need not necessarily indicate poor
prognosis, and all such patients need to be offered chemotherapy and at
least one of the bone-directed therapies (either local radiation in
cases of localized disease or bisphosphonates in the presence of
extensive disease) as they may have a better outcome with therapy.</description><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Blood clots</subject><subject>Bone cancer</subject><subject>Bone metastasis, hepatocellular carcinoma</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - drug therapy</subject><subject>Bone Neoplasms - secondary</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - secondary</subject><subject>Cancer</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Care and treatment</subject><subject>Case studies</subject><subject>Cisplatin - administration & dosage</subject><subject>Diagnosis</subject><subject>Diphosphonates - administration & dosage</subject><subject>Doxorubicin - administration & dosage</subject><subject>Fatal Outcome</subject><subject>Female</subject><subject>Hepatoma</subject><subject>Histology</subject><subject>Humans</subject><subject>Imidazoles - administration & dosage</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Liver Neoplasms - pathology</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Palliative Care</subject><subject>Patient outcomes</subject><subject>Radiography, Thoracic</subject><subject>Risk factors</subject><issn>0973-1482</issn><issn>1998-4138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1v1DAQhi0EokvhzA1ZIHHL1h9JbHMrFV9SVS5wtibOpLhK7GAnB_49Dru0Aq08kuXxM6N35iXkJWf7mjN5wYySFa-12NdCNOoR2XFjdFVzqR-T3f3vGXmW8x1jjRJCPyVnXLdac6F25OZ9DEgnXCCX8Jn6QH_gDEt0OI7rCIk6SM6HOME7eoPY0yEmmhDmOYHPMNI40KW8lwnD8pw8GWDM-OJ4n5PvHz98u_pcXX_99OXq8rrqGqaWqsgTEjqGpum4k0I5qA0araXhRrRMcaxbwXvsXNP0bgDHQTdKISgBBgZ5Tt4e-s4p_lwxL3byeVMMAeOabWtqxsuUBXz9H3gX1xSKNqtboRWToinQmwN0CyNaH4a4JHBbR3vJi1LOuNyo6gR1iwETjGWLgy_pf_j9Cb6cHifvThZcHApcijknHOyc_ATpl-XMbnbbzVC7GWr_2F0qXh2nW7sJ-wf-6O-Dhs7H0Qe8J1zyYP8mXSrBNCur-A1lurMD</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Attili, V. 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carcinoma (HCC), and often overlooked. We report two cases that had
isolated bone metastasis; one of them had prolonged disease-free
survival. The present series, along with the literature review,
reinforces the idea that HCC should be considered in the differential
diagnoses in patients presenting with metastases in bone. The presence
of isolated bone metastases need not necessarily indicate poor
prognosis, and all such patients need to be offered chemotherapy and at
least one of the bone-directed therapies (either local radiation in
cases of localized disease or bisphosphonates in the presence of
extensive disease) as they may have a better outcome with therapy.</abstract><cop>India</cop><pub>Medknow Publications on behalf of the Association of Radiation Oncologists of India (AROI)</pub><pmid>18688127</pmid><doi>10.4103/0973-1482.42257</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0973-1482 |
| ispartof | Journal of cancer research and therapeutics, 2008-04, Vol.4 (2), p.93-94 |
| issn | 0973-1482 1998-4138 |
| language | eng |
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| source | MEDLINE; Medknow Open Access Medical Journals; Bioline International; EZB-FREE-00999 freely available EZB journals |
| subjects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use Blood clots Bone cancer Bone metastasis, hepatocellular carcinoma Bone Neoplasms - diagnostic imaging Bone Neoplasms - drug therapy Bone Neoplasms - secondary Brain Neoplasms - diagnosis Brain Neoplasms - secondary Cancer Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - pathology Care and treatment Case studies Cisplatin - administration & dosage Diagnosis Diphosphonates - administration & dosage Doxorubicin - administration & dosage Fatal Outcome Female Hepatoma Histology Humans Imidazoles - administration & dosage Liver Neoplasms - drug therapy Liver Neoplasms - pathology Male Medical treatment Middle Aged Neoplasm Staging Palliative Care Patient outcomes Radiography, Thoracic Risk factors |
| title | Bone metastasis in hepatocellular carcinoma: Need for reappraisal of treatment |
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