An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever
Abstract The aim of this study was to stimulate immunity in the oro-nasal-pharyngeal region of cattle to protect them from alcelaphine herpesvirus-1 (AlHV-1)-induced malignant catarrhal fever. Attenuated C500 strain AlHV-1 was used along with Freund's adjuvant intramuscularly (IM) in the upper...
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| Veröffentlicht in: | Vaccine 2008-08, Vol.26 (35), p.4461-4468 |
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| creator | Haig, David M Grant, Dawn Deane, David Campbell, Iris Thomson, Jackie Jepson, Catherine Buxton, David Russell, George C |
| description | Abstract The aim of this study was to stimulate immunity in the oro-nasal-pharyngeal region of cattle to protect them from alcelaphine herpesvirus-1 (AlHV-1)-induced malignant catarrhal fever. Attenuated C500 strain AlHV-1 was used along with Freund's adjuvant intramuscularly (IM) in the upper neck region to immunise cattle. Virulent C500 strain AlHV-1 was used for intranasal challenge. Nine of ten cattle were protected. Protection was associated with high levels of neutralising antibody in nasal secretions. Some protected animals showed transient low levels of viral DNA in blood samples and in one lymph node sample after challenge whereas viral DNA was detected in the blood and in lymph node samples of all animals with MCF. This is the most promising immunisation strategy to date for the control of malignant catarrhal fever. |
| doi_str_mv | 10.1016/j.vaccine.2008.06.056 |
| format | Article |
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Attenuated C500 strain AlHV-1 was used along with Freund's adjuvant intramuscularly (IM) in the upper neck region to immunise cattle. Virulent C500 strain AlHV-1 was used for intranasal challenge. Nine of ten cattle were protected. Protection was associated with high levels of neutralising antibody in nasal secretions. Some protected animals showed transient low levels of viral DNA in blood samples and in one lymph node sample after challenge whereas viral DNA was detected in the blood and in lymph node samples of all animals with MCF. This is the most promising immunisation strategy to date for the control of malignant catarrhal fever.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2008.06.056</identifier><identifier>PMID: 18601965</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adjuvants, Immunologic - administration & dosage ; Allergy and Immunology ; Animals ; Antibodies, Viral - analysis ; Applied microbiology ; Biological and medical sciences ; Blood ; Cattle ; Deoxyribonucleic acid ; DNA ; DNA, Viral - blood ; Experiments ; Fever ; Freund's Adjuvant - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Gammaherpesvirinae - immunology ; Herpesvirus ; Immunization ; Injections, Intramuscular ; Lymph Nodes - virology ; Male ; Malignant Catarrh - prevention & control ; Malignant catarrhal Fever ; Medical sciences ; Microbiology ; Miscellaneous ; Mouth Mucosa - immunology ; Nasal Mucosa - immunology ; Neutralization Tests ; Pathology ; Pharynx - immunology ; Protected animals ; Rabbits ; Survival Analysis ; Tumors ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Vaccines, Attenuated - immunology ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; Viremia ; Virology</subject><ispartof>Vaccine, 2008-08, Vol.26 (35), p.4461-4468</ispartof><rights>Elsevier Ltd</rights><rights>2008 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Aug 18, 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-aed26bb3c8fe6cc6da41fd53c0c462cebd40656bff45f7cf7474999d8713fd293</citedby><cites>FETCH-LOGICAL-c507t-aed26bb3c8fe6cc6da41fd53c0c462cebd40656bff45f7cf7474999d8713fd293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1547166138?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999,64389,64391,64393,72473</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20602421$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18601965$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haig, David M</creatorcontrib><creatorcontrib>Grant, Dawn</creatorcontrib><creatorcontrib>Deane, David</creatorcontrib><creatorcontrib>Campbell, Iris</creatorcontrib><creatorcontrib>Thomson, Jackie</creatorcontrib><creatorcontrib>Jepson, Catherine</creatorcontrib><creatorcontrib>Buxton, David</creatorcontrib><creatorcontrib>Russell, George C</creatorcontrib><title>An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Abstract The aim of this study was to stimulate immunity in the oro-nasal-pharyngeal region of cattle to protect them from alcelaphine herpesvirus-1 (AlHV-1)-induced malignant catarrhal fever. Attenuated C500 strain AlHV-1 was used along with Freund's adjuvant intramuscularly (IM) in the upper neck region to immunise cattle. Virulent C500 strain AlHV-1 was used for intranasal challenge. Nine of ten cattle were protected. Protection was associated with high levels of neutralising antibody in nasal secretions. Some protected animals showed transient low levels of viral DNA in blood samples and in one lymph node sample after challenge whereas viral DNA was detected in the blood and in lymph node samples of all animals with MCF. This is the most promising immunisation strategy to date for the control of malignant catarrhal fever.</description><subject>Adjuvants, Immunologic - administration & dosage</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Viral - analysis</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Cattle</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA, Viral - blood</subject><subject>Experiments</subject><subject>Fever</subject><subject>Freund's Adjuvant - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gammaherpesvirinae - immunology</subject><subject>Herpesvirus</subject><subject>Immunization</subject><subject>Injections, Intramuscular</subject><subject>Lymph Nodes - virology</subject><subject>Male</subject><subject>Malignant Catarrh - prevention & control</subject><subject>Malignant catarrhal Fever</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mouth Mucosa - immunology</subject><subject>Nasal Mucosa - immunology</subject><subject>Neutralization Tests</subject><subject>Pathology</subject><subject>Pharynx - immunology</subject><subject>Protected animals</subject><subject>Rabbits</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Vaccine</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>Viremia</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2P0zAQhi0EYkvhJ4AsIbiljB3bSS6g1YovaSUOgMTNcp1x65I4xXYq9d_j0oqV9rInH_zM6xk_Q8hLBisGTL3brQ7GWh9wxQHaFagVSPWILFjb1BWXrH1MFsCVqASDX1fkWUo7AJA1656SK9YqYJ2SC3K8DtSP4xx8MtlPgaYcTcbNkbop0rxFuo9TRvvvbnLUmpwHpGZjfEiZmsHiYPbb0gfdYtxjOvg4p4pVPvSzxZ6OZvCbYEI-lZoYt2agDg8Yn5MnzgwJX1zOJfn56eOPmy_V7bfPX2-ubysrocmVwZ6r9bq2rUNlreqNYK6XtQUrFLe47gUoqdbOCeka6xrRiK7r-rZhtet5Vy_J23NuGeTPjCnr0afS9WACTnPSqhMAdVs_CLKuJHMuC_j6Hrib5hjKEJpJ0TClWMlbEnmmbJxSiuj0PvrRxKNmoE8K9U5fFOqTQg1KF4Wl7tUlfV6P2N9VXZwV4M0FMMmawUUTrE__OQ4KuOCscB_OHJbfPXiMOlmPoUjxsQjV_eQfbOX9vQQ7-ODLo7_xiOluap24Bv39tG-ndYO2hDCm6r-YTtPC</recordid><startdate>20080818</startdate><enddate>20080818</enddate><creator>Haig, David M</creator><creator>Grant, Dawn</creator><creator>Deane, David</creator><creator>Campbell, Iris</creator><creator>Thomson, Jackie</creator><creator>Jepson, Catherine</creator><creator>Buxton, David</creator><creator>Russell, George C</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080818</creationdate><title>An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever</title><author>Haig, David M ; Grant, Dawn ; Deane, David ; Campbell, Iris ; Thomson, Jackie ; Jepson, Catherine ; Buxton, David ; Russell, George C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-aed26bb3c8fe6cc6da41fd53c0c462cebd40656bff45f7cf7474999d8713fd293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adjuvants, Immunologic - administration & dosage</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Viral - analysis</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Cattle</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>DNA, Viral - blood</topic><topic>Experiments</topic><topic>Fever</topic><topic>Freund's Adjuvant - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gammaherpesvirinae - immunology</topic><topic>Herpesvirus</topic><topic>Immunization</topic><topic>Injections, Intramuscular</topic><topic>Lymph Nodes - virology</topic><topic>Male</topic><topic>Malignant Catarrh - prevention & control</topic><topic>Malignant catarrhal Fever</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mouth Mucosa - immunology</topic><topic>Nasal Mucosa - immunology</topic><topic>Neutralization Tests</topic><topic>Pathology</topic><topic>Pharynx - immunology</topic><topic>Protected animals</topic><topic>Rabbits</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Vaccine</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Vaccines, Attenuated - immunology</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>Viremia</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haig, David M</creatorcontrib><creatorcontrib>Grant, Dawn</creatorcontrib><creatorcontrib>Deane, David</creatorcontrib><creatorcontrib>Campbell, Iris</creatorcontrib><creatorcontrib>Thomson, Jackie</creatorcontrib><creatorcontrib>Jepson, Catherine</creatorcontrib><creatorcontrib>Buxton, David</creatorcontrib><creatorcontrib>Russell, George C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haig, David M</au><au>Grant, Dawn</au><au>Deane, David</au><au>Campbell, Iris</au><au>Thomson, Jackie</au><au>Jepson, Catherine</au><au>Buxton, David</au><au>Russell, George C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2008-08-18</date><risdate>2008</risdate><volume>26</volume><issue>35</issue><spage>4461</spage><epage>4468</epage><pages>4461-4468</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Abstract The aim of this study was to stimulate immunity in the oro-nasal-pharyngeal region of cattle to protect them from alcelaphine herpesvirus-1 (AlHV-1)-induced malignant catarrhal fever. Attenuated C500 strain AlHV-1 was used along with Freund's adjuvant intramuscularly (IM) in the upper neck region to immunise cattle. Virulent C500 strain AlHV-1 was used for intranasal challenge. Nine of ten cattle were protected. Protection was associated with high levels of neutralising antibody in nasal secretions. Some protected animals showed transient low levels of viral DNA in blood samples and in one lymph node sample after challenge whereas viral DNA was detected in the blood and in lymph node samples of all animals with MCF. This is the most promising immunisation strategy to date for the control of malignant catarrhal fever.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18601965</pmid><doi>10.1016/j.vaccine.2008.06.056</doi><tpages>8</tpages></addata></record> |
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| subjects | Adjuvants, Immunologic - administration & dosage Allergy and Immunology Animals Antibodies, Viral - analysis Applied microbiology Biological and medical sciences Blood Cattle Deoxyribonucleic acid DNA DNA, Viral - blood Experiments Fever Freund's Adjuvant - administration & dosage Fundamental and applied biological sciences. Psychology Gammaherpesvirinae - immunology Herpesvirus Immunization Injections, Intramuscular Lymph Nodes - virology Male Malignant Catarrh - prevention & control Malignant catarrhal Fever Medical sciences Microbiology Miscellaneous Mouth Mucosa - immunology Nasal Mucosa - immunology Neutralization Tests Pathology Pharynx - immunology Protected animals Rabbits Survival Analysis Tumors Vaccine Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Viremia Virology |
| title | An immunisation strategy for the protection of cattle against alcelaphine herpesvirus-1-induced malignant catarrhal fever |
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