Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly
Context: In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status. Objective: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,2...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2008-08, Vol.93 (8), p.3015-3020 |
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| creator | Romagnoli, Elisabetta Mascia, Maria Lucia Cipriani, Cristiana Fassino, Valeria Mazzei, Franco D'Erasmo, Emilio Carnevale, Vincenzo Scillitani, Alfredo Minisola, Salvatore |
| description | Context: In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status.
Objective: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d.
Design: This was a prospective randomized intervention study.
Setting: The study was performed in a nursing home residence.
Participants: A total of 32 elderly female patients (age range 66–97 yr), with vitamin D deficiency was included in the study.
Intervention: Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route.
Results: 25(OH)D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25(OH)D was significantly greater after cholecalciferol os administration (47.8 ± 7.3 ng/ml) compared with other forms (D3 im: 15.9 ± 11.3; D2 os: 17.3 ± 4.7; D2 im: 5 ± 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25(OH)D against time (AUC60) was: D3 os, 3193 ± 759 ng × d/ml vs. D2 os, 1820 ± 512, P < 0.001; and D3 im, 1361 ± 492 vs. D2 im, 728 ± 195, P < 0.01. 25(OH)D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037).
Conclusions: Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25(OH)D, when administered either by mouth or im. 25(OH)D plays a role in modulating serum PTH. |
| doi_str_mv | 10.1210/jc.2008-0350 |
| format | Article |
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Objective: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d.
Design: This was a prospective randomized intervention study.
Setting: The study was performed in a nursing home residence.
Participants: A total of 32 elderly female patients (age range 66–97 yr), with vitamin D deficiency was included in the study.
Intervention: Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route.
Results: 25(OH)D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25(OH)D was significantly greater after cholecalciferol os administration (47.8 ± 7.3 ng/ml) compared with other forms (D3 im: 15.9 ± 11.3; D2 os: 17.3 ± 4.7; D2 im: 5 ± 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25(OH)D against time (AUC60) was: D3 os, 3193 ± 759 ng × d/ml vs. D2 os, 1820 ± 512, P < 0.001; and D3 im, 1361 ± 492 vs. D2 im, 728 ± 195, P < 0.01. 25(OH)D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037).
Conclusions: Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25(OH)D, when administered either by mouth or im. 25(OH)D plays a role in modulating serum PTH.]]></description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.2008-0350</identifier><identifier>PMID: 18492750</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Calcitriol - blood ; Calcium - blood ; Cholecalciferol - administration & dosage ; Endocrinopathies ; Ergocalciferols - administration & dosage ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Medical sciences ; Parathyroid Hormone - blood ; Prospective Studies ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Vitamin D - analogs & derivatives ; Vitamin D - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 2008-08, Vol.93 (8), p.3015-3020</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-1113339bbda94e625a216a09f25eacce402f43e2dcb051039ce7ccb246a1bf4d3</citedby><cites>FETCH-LOGICAL-c467t-1113339bbda94e625a216a09f25eacce402f43e2dcb051039ce7ccb246a1bf4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20576785$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18492750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Romagnoli, Elisabetta</creatorcontrib><creatorcontrib>Mascia, Maria Lucia</creatorcontrib><creatorcontrib>Cipriani, Cristiana</creatorcontrib><creatorcontrib>Fassino, Valeria</creatorcontrib><creatorcontrib>Mazzei, Franco</creatorcontrib><creatorcontrib>D'Erasmo, Emilio</creatorcontrib><creatorcontrib>Carnevale, Vincenzo</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Minisola, Salvatore</creatorcontrib><title>Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description><![CDATA[Context: In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status.
Objective: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d.
Design: This was a prospective randomized intervention study.
Setting: The study was performed in a nursing home residence.
Participants: A total of 32 elderly female patients (age range 66–97 yr), with vitamin D deficiency was included in the study.
Intervention: Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route.
Results: 25(OH)D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25(OH)D was significantly greater after cholecalciferol os administration (47.8 ± 7.3 ng/ml) compared with other forms (D3 im: 15.9 ± 11.3; D2 os: 17.3 ± 4.7; D2 im: 5 ± 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25(OH)D against time (AUC60) was: D3 os, 3193 ± 759 ng × d/ml vs. D2 os, 1820 ± 512, P < 0.001; and D3 im, 1361 ± 492 vs. D2 im, 728 ± 195, P < 0.01. 25(OH)D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037).
Conclusions: Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25(OH)D, when administered either by mouth or im. 25(OH)D plays a role in modulating serum PTH.]]></description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Calcitriol - blood</subject><subject>Calcium - blood</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Endocrinopathies</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Parathyroid Hormone - blood</subject><subject>Prospective Studies</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1v00AQhleIiobCjTPaC4hKdTv7YTs-ojSlSJE4pES9Wev1ONnI3g2z9iF_iV-JrUT00tMc5pn3leZh7JOAWyEF3O3trQSYJ6BSeMNmotBpkosif8tmAFIkRS6fL9n7GPcAQutUvWOXYq4LmacwY3_Xu0A9N77mq-C3yRNSxzeGnOld8JE7z9dIQ8cXprUu9BQOzvLHQF3wGLlpeiRu-Nr5bYt8g3TkK0Nb5PchIg8NX9I22Om2QQot_7ZxvenG1Ht5zQPxxS60-OpeXU_l_Q75sq2R2uMHdtGYNuLH87xivx-WT4vHZPXrx8_F91VidZb3iRBCKVVUVW0KjZlMjRSZgaKRKRprUYNstEJZ2wpSAaqwmFtbSZ0ZUTW6Vlfs6yn3QOHPgLEvOxcttq3xGIZYZoUGGBtG8OYEWgoxEjblgVxn6FgKKCc35d6Wk5tycjPin8-5Q9Vh_QKfZYzAlzNg4viShoy3Lv7nJKR5ls_TkVMnDn0dLDmPB8IYy30YyI-feb3-H04dqMY</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Romagnoli, Elisabetta</creator><creator>Mascia, Maria Lucia</creator><creator>Cipriani, Cristiana</creator><creator>Fassino, Valeria</creator><creator>Mazzei, Franco</creator><creator>D'Erasmo, Emilio</creator><creator>Carnevale, Vincenzo</creator><creator>Scillitani, Alfredo</creator><creator>Minisola, Salvatore</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080801</creationdate><title>Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly</title><author>Romagnoli, Elisabetta ; Mascia, Maria Lucia ; Cipriani, Cristiana ; Fassino, Valeria ; Mazzei, Franco ; D'Erasmo, Emilio ; Carnevale, Vincenzo ; Scillitani, Alfredo ; Minisola, Salvatore</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-1113339bbda94e625a216a09f25eacce402f43e2dcb051039ce7ccb246a1bf4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Calcitriol - blood</topic><topic>Calcium - blood</topic><topic>Cholecalciferol - administration & dosage</topic><topic>Endocrinopathies</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Parathyroid Hormone - blood</topic><topic>Prospective Studies</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Romagnoli, Elisabetta</creatorcontrib><creatorcontrib>Mascia, Maria Lucia</creatorcontrib><creatorcontrib>Cipriani, Cristiana</creatorcontrib><creatorcontrib>Fassino, Valeria</creatorcontrib><creatorcontrib>Mazzei, Franco</creatorcontrib><creatorcontrib>D'Erasmo, Emilio</creatorcontrib><creatorcontrib>Carnevale, Vincenzo</creatorcontrib><creatorcontrib>Scillitani, Alfredo</creatorcontrib><creatorcontrib>Minisola, Salvatore</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Romagnoli, Elisabetta</au><au>Mascia, Maria Lucia</au><au>Cipriani, Cristiana</au><au>Fassino, Valeria</au><au>Mazzei, Franco</au><au>D'Erasmo, Emilio</au><au>Carnevale, Vincenzo</au><au>Scillitani, Alfredo</au><au>Minisola, Salvatore</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>93</volume><issue>8</issue><spage>3015</spage><epage>3020</epage><pages>3015-3020</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract><![CDATA[Context: In humans, few studies have compared the potencies of ergocalciferol and cholecalciferol in improving and maintaining vitamin D status.
Objective: Our objective was to evaluate the effects of a single very large dose of both calciferols on serum changes of 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], ionized calcium, and parathyroid hormone (PTH) at baseline, and at 3, 7, 30, and 60 d.
Design: This was a prospective randomized intervention study.
Setting: The study was performed in a nursing home residence.
Participants: A total of 32 elderly female patients (age range 66–97 yr), with vitamin D deficiency was included in the study.
Intervention: Participants were randomized into four groups of eight to receive a single dose of 300,000 IU ergocalciferol or cholecalciferol by oral (os) or im route.
Results: 25(OH)D levels sharply increased at d 3 only when vitamins were given os. The 30-d basal difference in serum 25(OH)D was significantly greater after cholecalciferol os administration (47.8 ± 7.3 ng/ml) compared with other forms (D3 im: 15.9 ± 11.3; D2 os: 17.3 ± 4.7; D2 im: 5 ± 4.4; all P < 0.001). The area under the curve (AUC) of the serum 25(OH)D against time (AUC60) was: D3 os, 3193 ± 759 ng × d/ml vs. D2 os, 1820 ± 512, P < 0.001; and D3 im, 1361 ± 492 vs. D2 im, 728 ± 195, P < 0.01. 25(OH)D significantly influences PTH levels at 3 (P < 0.03), 7 (P < 0.01), 30 (P < 0.01), and 60 d (P < 0.05). At 60 d, the form of vitamin (cholecalciferol) significantly lowers PTH levels (P = 0.037).
Conclusions: Cholecalciferol is almost twice as potent as ergocalciferol in increasing serum 25(OH)D, when administered either by mouth or im. 25(OH)D plays a role in modulating serum PTH.]]></abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>18492750</pmid><doi>10.1210/jc.2008-0350</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2008-08, Vol.93 (8), p.3015-3020 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69400339 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Biological and medical sciences Calcitriol - blood Calcium - blood Cholecalciferol - administration & dosage Endocrinopathies Ergocalciferols - administration & dosage Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Medical sciences Parathyroid Hormone - blood Prospective Studies Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Vitamin D - analogs & derivatives Vitamin D - blood |
| title | Short and Long-Term Variations in Serum Calciotropic Hormones after a Single Very Large Dose of Ergocalciferol (Vitamin D2) or Cholecalciferol (Vitamin D3) in the Elderly |
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