Differential Requirement for the SAP-Fyn Interaction during NK T Cell Development and Function

The adaptor molecule SAP (signaling lymphocytic activation molecule-associated protein) plays a critical role during NK T (NKT) cell development in humans and mice. In CD4(+) T cells, SAP interacts with the tyrosine kinase Fyn to deliver signals required for TCR-induced Th2-type cytokine production....

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Veröffentlicht in:	The Journal of immunology (1950) 2008-08, Vol.181 (4), p.2311-2320
Hauptverfasser:	Nunez-Cruz, Selene, Yeo, W. C. Janice, Rothman, Jennifer, Ojha, Priti, Bassiri, Hamid, Juntilla, Marisa, Davidson, Dominique, Veillette, Andre, Koretzky, Gary A, Nichols, Kim E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Differentiation - immunology Cell Line Coculture Techniques Intracellular Signaling Peptides and Proteins - deficiency Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Intracellular Signaling Peptides and Proteins - physiology Killer Cells, Natural - cytology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte Activation - genetics Lymphocyte Activation - immunology Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Proto-Oncogene Proteins c-fyn - deficiency Proto-Oncogene Proteins c-fyn - genetics Proto-Oncogene Proteins c-fyn - metabolism Proto-Oncogene Proteins c-fyn - physiology Signal Transduction - genetics Signal Transduction - immunology Signaling Lymphocytic Activation Molecule Associated Protein T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
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