A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion
Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. In this manuscript, we present a new concept towards a definition of a melatonin defic...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 1999-12, Vol.21 (6), p.765-772 |
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| container_title | Neuropsychopharmacology (New York, N.Y.) |
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| creator | Kunz, Dieter Schmitz, Stephan Mahlberg, Richard Mohr, Anabelle Stöter, Christiane Wolf, Karl-Jürgen Herrmann, Werner Martin |
| description | Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. In this manuscript, we present a new concept towards a definition of a melatonin deficit. The purpose of the study was to introduce a marker for an intra-individual decrease in melatonin production. Therefore, we developed a method to quantify the degree of pineal calcification (DOC) using cranial computed tomography. Combining pineal DOC with the organs's size, we estimated the uncalcified pineal gland volume. This estimation was positively and significantly associated with 6-sulfatoxymelatonin (aMT6s), collected over 24 hours in urine, in 26 subjects. Data yielded evidence that the decline in aMT6s excretion with age can be sufficiently explained by an increased pineal calcification. These results suggest that DOC might be useful as an indicator of an intra-individual, decreased capability of the pineal gland to produce melatonin. DOC might prove to be a response-marker for melatonin replacement therapy and a vulnerability marker of the circadian timing system. |
| doi_str_mv | 10.1016/S0893-133X(99)00069-X |
| format | Article |
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DOC might prove to be a response-marker for melatonin replacement therapy and a vulnerability marker of the circadian timing system.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(99)00069-X</identifier><identifier>PMID: 10633482</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Calcification ; Calcinosis - complications ; Calcinosis - diagnostic imaging ; Calcinosis - physiopathology ; Circadian timing system ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Male ; Melatonin ; Melatonin - analogs & derivatives ; Melatonin - deficiency ; Melatonin - physiology ; Melatonin - urine ; Middle Aged ; Morphology. Functional localizations ; Pineal gland ; Pineal Gland - diagnostic imaging ; Pineal Gland - pathology ; Pineal Gland - physiopathology ; Reference Values ; Sleep ; Sleep Wake Disorders - diagnostic imaging ; Sleep Wake Disorders - etiology ; Sleep Wake Disorders - physiopathology ; Tomography, X-Ray Computed ; Vertebrates: endocrinology</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 1999-12, Vol.21 (6), p.765-772</ispartof><rights>1999 American College of Neuropsychopharmacology</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-8bacb40bf12fca4aeb1086eb43b2ac1c8dffe1fbc3615fbe48974c7f54225caa3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1227649$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10633482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kunz, Dieter</creatorcontrib><creatorcontrib>Schmitz, Stephan</creatorcontrib><creatorcontrib>Mahlberg, Richard</creatorcontrib><creatorcontrib>Mohr, Anabelle</creatorcontrib><creatorcontrib>Stöter, Christiane</creatorcontrib><creatorcontrib>Wolf, Karl-Jürgen</creatorcontrib><creatorcontrib>Herrmann, Werner Martin</creatorcontrib><title>A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. 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DOC might prove to be a response-marker for melatonin replacement therapy and a vulnerability marker of the circadian timing system.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Calcification</subject><subject>Calcinosis - complications</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - physiopathology</subject><subject>Circadian timing system</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - analogs & derivatives</subject><subject>Melatonin - deficiency</subject><subject>Melatonin - physiology</subject><subject>Melatonin - urine</subject><subject>Middle Aged</subject><subject>Morphology. Functional localizations</subject><subject>Pineal gland</subject><subject>Pineal Gland - diagnostic imaging</subject><subject>Pineal Gland - pathology</subject><subject>Pineal Gland - physiopathology</subject><subject>Reference Values</subject><subject>Sleep</subject><subject>Sleep Wake Disorders - diagnostic imaging</subject><subject>Sleep Wake Disorders - etiology</subject><subject>Sleep Wake Disorders - physiopathology</subject><subject>Tomography, X-Ray Computed</subject><subject>Vertebrates: endocrinology</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi1ERZfCTwD5gBAcAnbsODEXVC2FIhWKRJH2Zo0nY8ko62ztLLT_nmx3Bb1xGmn0vPPxMPZMijdSSPP2u-isqqRSq1fWvhZCGFutHrCFbLWojNKrh2zxFzlmj0v5KYRsWtM9YsdSGKV0Vy_Y1Sn_Sr_5ckxIm4mHMfMvNMA0ppj4BwoR4_SOXyb-LSaCgS9hwDh3YYpj4pD6e_jZDWba9Z-wowBDoaeHesJ-fDy7Wp5XF5efPi9PLypshJqqzgN6LXyQdUDQQF6KzpDXyteAErs-BJLBozKyCZ50Z1uNbWh0XTcIoE7Yy_3cTR6vt1Qmt44FaRgg0bgtzlg9_6zFDDZ7EPNYSqbgNjmuId86KdxOp7vT6XaunLXuTqdbzbnnhwVbv6b-XmrvbwZeHAAoCEPIkDCWf1xdt0bbGXu_x2i28StSdgUjzcr7mAkn14_xP5f8AWmwkus</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Kunz, Dieter</creator><creator>Schmitz, Stephan</creator><creator>Mahlberg, Richard</creator><creator>Mohr, Anabelle</creator><creator>Stöter, Christiane</creator><creator>Wolf, Karl-Jürgen</creator><creator>Herrmann, Werner Martin</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion</title><author>Kunz, Dieter ; Schmitz, Stephan ; Mahlberg, Richard ; Mohr, Anabelle ; Stöter, Christiane ; Wolf, Karl-Jürgen ; Herrmann, Werner Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-8bacb40bf12fca4aeb1086eb43b2ac1c8dffe1fbc3615fbe48974c7f54225caa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Calcification</topic><topic>Calcinosis - complications</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - physiopathology</topic><topic>Circadian timing system</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - analogs & derivatives</topic><topic>Melatonin - deficiency</topic><topic>Melatonin - physiology</topic><topic>Melatonin - urine</topic><topic>Middle Aged</topic><topic>Morphology. Functional localizations</topic><topic>Pineal gland</topic><topic>Pineal Gland - diagnostic imaging</topic><topic>Pineal Gland - pathology</topic><topic>Pineal Gland - physiopathology</topic><topic>Reference Values</topic><topic>Sleep</topic><topic>Sleep Wake Disorders - diagnostic imaging</topic><topic>Sleep Wake Disorders - etiology</topic><topic>Sleep Wake Disorders - physiopathology</topic><topic>Tomography, X-Ray Computed</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kunz, Dieter</creatorcontrib><creatorcontrib>Schmitz, Stephan</creatorcontrib><creatorcontrib>Mahlberg, Richard</creatorcontrib><creatorcontrib>Mohr, Anabelle</creatorcontrib><creatorcontrib>Stöter, Christiane</creatorcontrib><creatorcontrib>Wolf, Karl-Jürgen</creatorcontrib><creatorcontrib>Herrmann, Werner Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kunz, Dieter</au><au>Schmitz, Stephan</au><au>Mahlberg, Richard</au><au>Mohr, Anabelle</au><au>Stöter, Christiane</au><au>Wolf, Karl-Jürgen</au><au>Herrmann, Werner Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>21</volume><issue>6</issue><spage>765</spage><epage>772</epage><pages>765-772</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>Even though exogenous melatonin has proven to influence sleep and circadian parameters, low endogenous melatonin is not related to sleep disturbances, nor does it predict response to melatonin replacement therapy. In this manuscript, we present a new concept towards a definition of a melatonin deficit. The purpose of the study was to introduce a marker for an intra-individual decrease in melatonin production. Therefore, we developed a method to quantify the degree of pineal calcification (DOC) using cranial computed tomography. Combining pineal DOC with the organs's size, we estimated the uncalcified pineal gland volume. This estimation was positively and significantly associated with 6-sulfatoxymelatonin (aMT6s), collected over 24 hours in urine, in 26 subjects. Data yielded evidence that the decline in aMT6s excretion with age can be sufficiently explained by an increased pineal calcification. These results suggest that DOC might be useful as an indicator of an intra-individual, decreased capability of the pineal gland to produce melatonin. 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| subjects | Adolescent Adult Aged Biological and medical sciences Calcification Calcinosis - complications Calcinosis - diagnostic imaging Calcinosis - physiopathology Circadian timing system Female Fundamental and applied biological sciences. Psychology Humans Hypothalamus. Hypophysis. Epiphysis. Urophysis Male Melatonin Melatonin - analogs & derivatives Melatonin - deficiency Melatonin - physiology Melatonin - urine Middle Aged Morphology. Functional localizations Pineal gland Pineal Gland - diagnostic imaging Pineal Gland - pathology Pineal Gland - physiopathology Reference Values Sleep Sleep Wake Disorders - diagnostic imaging Sleep Wake Disorders - etiology Sleep Wake Disorders - physiopathology Tomography, X-Ray Computed Vertebrates: endocrinology |
| title | A New Concept for Melatonin Deficit: On Pineal Calcification and Melatonin Excretion |
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