Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants

Mechanisms by which gut luminal content regulates secretion and motility are ill understood. We evaluated whether neuroendocrine enterochromaffin (EC) cells act as luminal sensors for a wide variety of nutrients and defined the secretory mechanisms of this process. Pure (98-99%) FACS-sorted human EC...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2008-08, Vol.295 (2), p.G260-G272
Hauptverfasser:	Kidd, Mark, Modlin, Irvin M, Gustafsson, Bjorn I, Drozdov, Ignat, Hauso, Oyvind, Pfragner, Roswitha
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System A - physiology Bile Acids and Salts - physiology Caffeine - pharmacology Carcinoid Tumor - genetics Carcinoid Tumor - metabolism Cell Line, Tumor Cells Deoxycholic Acid - pharmacology Deoxyglucose - pharmacology Digestive system Endocrine system Enterochromaffin Cells - drug effects Enterochromaffin Cells - metabolism Extracellular Signal-Regulated MAP Kinases - physiology Genes Glucose Transport Proteins, Facilitative - physiology Glutamine - pharmacology Hormones Humans Intestinal Neoplasms - genetics Intestinal Neoplasms - metabolism Intestine, Small Organic Anion Transporters, Sodium-Dependent - physiology Proteins Receptors, G-Protein-Coupled - physiology Receptors, Metabotropic Glutamate - physiology Receptors, Odorant - physiology Serotonin - metabolism Sodium-Glucose Transporter 1 - physiology Somatostatin - pharmacology Sucrose - analogs & derivatives Sucrose - pharmacology Symporters - physiology Tyrosine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!