Astrocyte gp130 Expression Is Critical for the Control of Toxoplasma Encephalitis

Toxoplasma gondii infects astrocytes, neurons and microglia cells in the CNS and, after acute encephalitis, persists within neurons. Robust astrocyte activation is a hallmark of Toxoplasma encephalitis (TE); however, the in vivo function of astrocytes is largely unknown. To study their role in TE we...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-08, Vol.181 (4), p.2683-2693
Hauptverfasser:	Drogemuller, Katrin, Helmuth, Ulrike, Brunn, Anna, Sakowicz-Burkiewicz, Monika, Gutmann, David H, Mueller, Werner, Deckert, Martina, Schluter, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - immunology Astrocytes - metabolism Astrocytes - parasitology Cell Survival - genetics Cell Survival - immunology Cells, Cultured Cytokine Receptor gp130 - biosynthesis Cytokine Receptor gp130 - deficiency Cytokine Receptor gp130 - genetics Cytokine Receptor gp130 - metabolism Female Glial Fibrillary Acidic Protein Humans Ligands Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Signal Transduction - genetics Signal Transduction - immunology Toxoplasmosis, Cerebral - immunology Toxoplasmosis, Cerebral - metabolism Toxoplasmosis, Cerebral - pathology Toxoplasmosis, Cerebral - prevention & control Up-Regulation - genetics Up-Regulation - immunology
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