Epidermal growth factor induces changes of interaction between epidermal growth factor receptor and actin in intact cells

The epidermal growth factor receptor (EGFR) is a cytoskeleton-binding protein. Although purified EGFR can interact with actins in vitro and normally at least 10% of EGFR exist in the insoluble cytoskeleton fraction of A431 cells, interaction of cytosolic EGFR with actin can only be visualized by flu...

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Veröffentlicht in:	Acta biochimica et biophysica Sinica 2008-08, Vol.40 (8), p.754-760
Hauptverfasser:	Song, Wei, Xuan, Haixing, Lin, Qishui
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - chemistry Actins - genetics Actins - metabolism Animals Cell Line Cercopithecus aethiops COS Cells Cytoskeleton - metabolism Epidermal Growth Factor - genetics Epidermal Growth Factor - metabolism Epidermal Growth Factor - pharmacology Fluorescence Resonance Energy Transfer Humans Luminescent Proteins - genetics Luminescent Proteins - metabolism Protein Interaction Domains and Motifs Receptor, Epidermal Growth Factor - chemistry Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - pharmacology Signal Transduction - drug effects
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