Variability of Adenovirus Receptor Density Influences Gene Transfer Efficiency and Therapeutic Response in Head and Neck Cancer

Despite encouraging preclinical studies in many tumor types including head and neck squamous cell carcinoma (HNSCC), initial clinical trials with adenovirus-mediated gene therapy have been disappointing. Although the adenovirus is a âhighly efficient vector,â it is still limited by the extent of...

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Veröffentlicht in:	Clinical cancer research 1999-12, Vol.5 (12), p.4175-4181
Hauptverfasser:	Li, D, Duan, L, Freimuth, P, O'Malley, Jr, B W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - genetics Adenoviruses, Human - metabolism Animals Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors - genetics Green Fluorescent Proteins Head and Neck Neoplasms - genetics Head and Neck Neoplasms - therapy Humans Interleukin-2 - biosynthesis Interleukin-2 - genetics Luminescent Proteins - biosynthesis Luminescent Proteins - genetics Medical sciences Mice Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Receptors, Virus - metabolism Thymidine Kinase - biosynthesis Thymidine Kinase - genetics Tumor Cells, Cultured Tumors
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