Age-related Changes in the Kinetics of Water Transport in Normal Human Lenses

Magnetic resonance microscopy (MRM) has been used to study the kinetics of water transport in human eye lenses. Fresh lenses obtained from the Queensland Eye Bank were incubated at 34.5°C in artificial aqueous humour (AAH) containing nutrients and metabolites similar to those that are present in viv...

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Veröffentlicht in:	Experimental eye research 1999-12, Vol.69 (6), p.663-669
Hauptverfasser:	MOFFAT, B.A, LANDMAN, K.A, TRUSCOTT, R.J.W, SWEENEY, M.H.J, POPE, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Biological and medical sciences Body Water - metabolism cataract Cataract - etiology deuterium oxide (D2O) Diffusion Eye and associated structures. Visual pathways and centers. Vision eye lens Fundamental and applied biological sciences. Psychology Humans Lens, Crystalline - metabolism Magnetic Resonance Spectroscopy Models, Biological Organ Culture Techniques presbyopia Presbyopia - etiology Vertebrates: nervous system and sense organs water transport
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Zusammenfassung:	Magnetic resonance microscopy (MRM) has been used to study the kinetics of water transport in human eye lenses. Fresh lenses obtained from the Queensland Eye Bank were incubated at 34.5°C in artificial aqueous humour (AAH) containing nutrients and metabolites similar to those that are present in vivo. MR images were acquired over approximately a 20 hr period following replacement of H2O based AAH with deuterium oxide (D2O) based AAH. NMR signal intensity from the lenses decreased with time corresponding to a decrease in concentration of H2O within the lenses. A statistically significant correlation (P
ISSN:	0014-4835 1096-0007
DOI:	10.1006/exer.1999.0747