copper(II)-selective chelator ameliorates diabetes-evoked renal fibrosis and albuminuria, and suppresses pathogenic TGF-β activation in the kidneys of rats used as a model of diabetes

Aims/hypothesis The selective CuII chelator triethylenetetramine (TETA) extracts systemic CuII into the urine of diabetic humans and rats as a model of diabetes, and in the process also normalises hallmarks of diabetic heart disease. However, the role of Cu and its response to TETA in animals with d...

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Veröffentlicht in:	Diabetologia 2008-09, Vol.51 (9), p.1741-1751
Hauptverfasser:	Gong, D, Lu, J, Chen, X, Reddy, S, Crossman, D. J, Glyn-Jones, S, Choong, Y.-S, Kennedy, J, Barry, B, Zhang, S, Chan, Y.-K, Ruggiero, K, Phillips, A. R. J, Cooper, G. J. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria Albuminuria - drug therapy Animals Associated diseases and complications Biological and medical sciences Chelating Agents - therapeutic use Copper - therapeutic use Diabetes Mellitus, Experimental - drug therapy Diabetes. Impaired glucose tolerance Diabetic Nephropathies - drug therapy diabetic nephropathy Disease Models, Animal Divalent copper Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance extracellular matrix Fibrosis Glomerular hypertrophy Human Physiology Internal Medicine Kidney - drug effects Kidney - pathology Kidney Glomerulus - drug effects Kidney Glomerulus - pathology Kidneys Medical sciences Medicine Medicine & Public Health Metabolic Diseases Nephrology. Urinary tract diseases Rats Semicarbazide-sensitive amine oxidase SSAO TGF-β Transforming Growth Factor beta - antagonists & inhibitors Trientine - therapeutic use Triethylenetetramine Urinary system involvement in other diseases. Miscellaneous
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